Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Shih-Pai Road, Sec. 2, 11217, Taipei, Taiwan.
Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
J Autism Dev Disord. 2023 Nov;53(11):4457-4464. doi: 10.1007/s10803-022-05732-7. Epub 2022 Sep 8.
The association between autism spectrum disorder (ASD) and subsequent sexually transmitted infections (STIs) and the potential effects of medications on STI risk remain unknown. In all, 5076 adolescents and young adults with ASD and 57,060 age-/sex-matched individuals without ASD were enrolled between 2001 and 2009 and followed-up to the end of 2011 for identification of subsequent STIs. The results revealed that patients with ASD were prone to acquiring an STI [hazard ratio (HR) 3.36] compared with the comparison group. Long-term use of atypical antipsychotics was associated with a lower risk of acquiring an STI later in life compared with nonuse (HR 0.34). We recommend that clinicians closely monitor risky sexual behaviors and STI risk in patients with ASD.
自闭症谱系障碍（ASD）与随后的性传播感染（STIs）之间的关联，以及药物对 STI 风险的潜在影响尚不清楚。在 2001 年至 2009 年间，共招募了 5076 名患有 ASD 的青少年和年轻人，以及 57060 名年龄/性别匹配的无 ASD 个体，并随访至 2011 年底，以确定随后的 STIs。结果表明，与对照组相比，ASD 患者更容易感染 STI（风险比[HR]3.36）。与不使用相比，长期使用非典型抗精神病药物与较低的性传播感染风险相关（HR 0.34）。我们建议临床医生密切监测 ASD 患者的危险性行为和 STI 风险。
