Department of Pediatric Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Key Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Biomed Pharmacother. 2022 Sep;153:113513. doi: 10.1016/j.biopha.2022.113513. Epub 2022 Aug 5.
Since the discovery of the nuclear factor kappa B (NF-ĸB) transcription factor 36 years ago, many studies have linked the NF-ĸB signaling pathway to pathological and physiological processes, such as inflammation, immune response, and tumorigenesis. However, as the NF-ĸB signaling pathway is evolutionarily conserved from flies to humans, an increasing number of studies have focused on the impact of NF-ĸB signaling on developmental processes. While our understanding of the mechanisms underlying NF-ĸB signaling involved in tissue and organ development is limited, the numerous studies conducted in recent years have provided preliminary insights into these molecular mechanisms. In this review, we summarize the latest information on the molecular mechanisms behind NF-ĸB signaling involved in tissue and organ development, highlighting the role and significance of the NF-ĸB signaling pathway in developmental processes. This review elucidates the fact that the development of nearly all tissues is associated with NF-ĸB signaling, either directly or indirectly.
36 年前发现核因子 kappa B（NF-κB）转录因子以来，许多研究已经将 NF-κB 信号通路与炎症、免疫反应和肿瘤发生等病理和生理过程联系起来。然而，由于 NF-κB 信号通路在从苍蝇到人类的进化过程中是保守的，因此越来越多的研究集中在 NF-κB 信号对发育过程的影响上。虽然我们对 NF-κB 信号在组织和器官发育中所涉及的机制的理解是有限的，但近年来进行的大量研究为这些分子机制提供了初步的认识。在这篇综述中，我们总结了 NF-κB 信号在组织和器官发育中所涉及的分子机制的最新信息，强调了 NF-κB 信号通路在发育过程中的作用和意义。这篇综述阐明了这样一个事实，即几乎所有组织的发育都与 NF-κB 信号直接或间接相关。
