Department of Immunology, School of Medicine, UConn Health, Farmington, CT, United States.
Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Front Immunol. 2022 Aug 19;13:934444. doi: 10.3389/fimmu.2022.934444. eCollection 2022.
Neutrophils are the most abundant leukocyte in human blood. They are critical for fighting infections and are involved in inflammatory diseases. Mitochondria are indispensable for eukaryotic cells, as they control the biochemical processes of respiration and energy production. Mitochondria in neutrophils have been underestimated since glycolysis is a major metabolic pathway for fuel production in neutrophils. However, several studies have shown that mitochondria are greatly involved in multiple neutrophil functions as well as neutrophil-related diseases. In this review, we focus on how mitochondrial components, metabolism, and related genes regulate neutrophil functions and relevant diseases.
中性粒细胞是人体血液中最丰富的白细胞。它们对于抗感染至关重要，并且参与炎症性疾病。线粒体对于真核细胞是不可或缺的，因为它们控制着呼吸和能量产生的生化过程。由于糖酵解是中性粒细胞产生燃料的主要代谢途径，因此中性粒细胞中的线粒体一直被低估。然而，几项研究表明，线粒体在多种中性粒细胞功能以及与中性粒细胞相关的疾病中都有很大的作用。在这篇综述中，我们重点讨论了线粒体成分、代谢和相关基因如何调节中性粒细胞功能和相关疾病。
