脆性位点与相互易位断点无关。
Fragile sites are unrelated to reciprocal translocation breakpoints.
作者信息
Davis J R, Hagaman R M
出版信息
Clin Genet. 1987 May;31(5):308-10. doi: 10.1111/j.1399-0004.1987.tb02813.x.
Abstract
In 492 cases of reciprocal translocations in balanced carriers, the 984 breakpoints were studied for a possible relationship to the 45 fragile sites. Random coincidence was predicted at 14% and the observed coincidence was 14.3%, indicating that the two events are unrelated. However, chromosomes 1, 11 and 14 were exceptions and did show a statistically significant relationship.
摘要
在492例平衡携带者的相互易位病例中，对984个断点进行了研究，以探讨其与45个脆性位点之间可能存在的关系。预计随机巧合率为14%，而观察到的巧合率为14.3%，这表明这两个事件并无关联。然而，1号、11号和14号染色体是例外，它们确实显示出具有统计学意义的关系。
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