Davis B R, Curb J D, Tung B, Hawkins C M, Ehrman S, Farmer J, Martin M
Control Clin Trials. 1987 Jun;8(2):110-20. doi: 10.1016/0197-2456(87)90036-5.
One method for determining cause of death in a clinical trial is to use standard nosological coding of death certificates. In order to look at an alternative approach, the Hypertension Detection and Follow-up Program (HDFP) assessed underlying causes of death through the use of three physicians. These physicians were trained and standardized in the proper recording of cause of death on death certificates. Each physician completed a death certificate for each of the 768 deaths in the HDFP, utilizing all available information, including HDFP records, plus any additional hospital and autopsy records. The new standardized death certificates were then transmitted to a panel of three nosologists who coded the cause of death. The physician preparation procedure was compared with a procedure wherein a panel of three nosologists coded the original death certificate for the underlying cause of death. The procedures agreed on the three-digit International Classification of Disease, Adapted code in 60.1% of the cases. The agreement rate improved to 72.5% when disease codes were collapsed into broad disease categories utilized in the HDFP.
在临床试验中确定死亡原因的一种方法是使用死亡证明的标准疾病分类编码。为了探讨另一种方法，高血压检测与随访项目（HDFP）通过三名医生评估潜在死亡原因。这些医生在正确记录死亡证明上的死亡原因方面接受了培训并实现了标准化。每位医生利用所有可用信息，包括HDFP记录以及任何额外的医院和尸检记录，为HDFP中的768例死亡病例分别填写了一份死亡证明。然后，新的标准化死亡证明被传送给一个由三名疾病分类学家组成的小组，由他们对死亡原因进行编码。将医生准备程序与由三名疾病分类学家组成的小组对原始死亡证明的潜在死亡原因进行编码的程序进行了比较。在60.1%的病例中，两种程序在三位数字的国际疾病分类改编代码上达成了一致。当疾病代码合并为HDFP中使用的广泛疾病类别时，一致率提高到了72.5%。
