Magnetometer-free Kalman filter for motor-based assessment of prodromal Parkinson's disease.

Observing the kinematics of specific motor tasks, such as finger tapping (FT), provides an objective and consistent quantification of the severity of neurodegenerative diseases. However, the current clinical practice mostly relies on visual observations performed by the clinician. Thus, the assessment is subjective. In this paper, we propose a magnetometer-free Kalman filter (KF) to assess FT features using wearable, inertial sensors. The KF was used to assess features during two different FT tasks, namely forefinger tapping (FTAP) and thumb-forefinger tapping (THFF). The proposed KF was validated against a camera-based reference and compared with a strap-down integration-based method. Comparison between KF method and camera reference showed low discrepancies in terms of root mean square error (RMSE) for considered features: namely number of repetitions (RMSE < 0.7), tapping frequency (RMSE < 0.1 Hz), and amplitude (RMSE < 2.6 deg). An high correlation coefficient between amplitudes was also obtained. The proposed KF performed better than the strap-down integration method on both FT tasks, showing lower RMSE on every feature as well as a higher correlation coefficient. Clinical Relevance- The wearable setup, as well as the proposed magnetometer-free KF, may provide a low-cost, easyto- use, non-invasive motion tracking system for protocols aimed to assess motor performances in neurodegenerative disorders.