Department of Orthopedic Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Department of Pathology and Oncology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Medicine (Baltimore). 2022 Sep 9;101(36):e30127. doi: 10.1097/MD.0000000000030127.
The purpose of the present study was to clarify clinical outcomes of elderly patients with soft tissue sarcoma who underwent surgery neither with neoadjuvant nor adjuvant chemotherapy. The median follow-up period was 46.3 (range 6.7-99.0) months. All patients underwent surgical resections. R0 margins were achieved in 24 cases (92.3%) and R1 margins in 2 cases (7.7%). The 1-, 2-, and 5-year sarcoma-specific survival (SSS) rates were 92.3%, 88.5%, and 83.8%, respectively. Multivariate analysis showed no significant risk factors for SSS. No significant relationship of histological grades and local recurrences (P = .56) or distant metastases (P = .54) was shown. In the current study, we observed a comparable survival ratio, despite no neoadjuvant or adjuvant chemotherapies performed. Tumor resections with adequate margins might, at least in part, have contributed to the decent survival ratio regardless of histological grade. Twenty-six consecutive patients aged ≥ 70 years, who underwent surgical resections of soft tissue sarcoma between January 2013 and December 2019, were included. SSS were analyzed by the Kaplan-Meier method, and the relationships between SSS and clinical parameters were evaluated by Cox proportional hazards analysis.
本研究旨在阐明未接受新辅助或辅助化疗的老年软组织肉瘤患者的临床结局。中位随访时间为 46.3 个月(范围 6.7-99.0)。所有患者均接受了手术切除。24 例(92.3%)达到 R0 切缘,2 例(7.7%)达到 R1 切缘。1、2 和 5 年的肉瘤特异性生存率(SSS)分别为 92.3%、88.5%和 83.8%。多因素分析显示 SSS 无显著危险因素。组织学分级与局部复发(P=.56)或远处转移(P=.54)无显著相关性。在本研究中,我们观察到了相当的生存率,尽管没有进行新辅助或辅助化疗。肿瘤切除时达到足够的切缘可能至少部分有助于良好的生存率,而与组织学分级无关。2013 年 1 月至 2019 年 12 月期间,连续 26 例年龄≥70 岁的软组织肉瘤患者接受了手术切除,分析了 SSS。采用 Kaplan-Meier 法进行 SSS 分析,Cox 比例风险分析评估 SSS 与临床参数的关系。