Ramírez Simón, Miguez Gonzalo, Quezada-Scholz Vanetza E, Pardo Luis, Alfaro Felipe, Varas Felipe I, Laborda Mario A
Department of Psychology, Universidad de Chile, Santiago, Chile.
Department of Social Sciences and Humanities, Universidad de Aysén, Coyhaique, Chile.
Front Psychol. 2022 Aug 26;13:934600. doi: 10.3389/fpsyg.2022.934600. eCollection 2022.
Pre and perinatal administration of Tetrahydrocannabinol (THC) in rodents and their offspring has many effects that have been studied using different methods that have not been integrated using quantitative methods. The effect of THC administration on behavior can be better understood by meta-analytic techniques. We examined whether there is an overall effect on the behavior of the offspring when THC is administered to mothers. Eligibility criteria included experiments using an experimental design with a control group without THC, in which THC is administered to mothers during pregnancy and lactation in rodents, and in which at least one type of behavioral (locomotor, emotional or cognitive) measurement in the offspring was implemented. Cohen's was obtained for each study, then each individual study was weighted, and moderator analysis was performed. Analysis was performed using fixed and random effect models, and the heterogeneity was assessed by calculating Qb, and the prediction interval. Furthermore, 3 sub-meta-analyses were carried out according to the type of behavior. The general analysis determined a low weighted effect size of THC on the behavior of the offspring, moderated by type of rat strain. The sub-meta-analyses showed a medium effect for cognitive effects of THC in the offspring, and a low effect on locomotor activity and emotional behavior. In addition, publication bias was not detected. More research is needed to contribute to the understanding of the effect of THC exposure on offspring.
在啮齿动物及其后代中进行四氢大麻酚（THC）的产前和围产期给药，会产生许多影响，人们已使用不同方法对这些影响展开研究，但尚未采用定量方法进行整合。通过荟萃分析技术，可以更好地理解THC给药对行为的影响。我们研究了在给母鼠注射THC时，对其后代的行为是否存在总体影响。纳入标准包括采用一种实验设计的实验，该设计设有一个未注射THC的对照组，在啮齿动物的孕期和哺乳期给母鼠注射THC，并且对后代实施至少一种行为（运动、情绪或认知）测量。为每项研究计算科恩效应量，然后对每项单独研究进行加权，并进行调节因素分析。使用固定效应模型和随机效应模型进行分析，并通过计算Qb、I²和预测区间来评估异质性。此外，根据行为类型进行了3项子荟萃分析。总体分析确定，THC对后代行为的加权效应量较低，受大鼠品系类型的调节。子荟萃分析显示，THC对后代认知效应有中等影响，对运动活动和情绪行为有低等影响。此外，未检测到发表偏倚。需要更多研究来促进对THC暴露对后代影响的理解。
