Department of Surgery, Veterans General Hospital, Taipei, Taiwan.
Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
ANZ J Surg. 2023 Jan;93(1-2):182-195. doi: 10.1111/ans.18014. Epub 2022 Sep 12.
Accumulating evidence has reported a high correlation between inflammatory markers and oncological outcomes in colorectal cancer. In the present study, we aimed to assess the prognostic values of five inflammatory markers in stage II colon cancer patients with different tumour locations.
The consecutive stage II colon adenocarcinoma patients undergoing curative resection were analysed retrospectively. ROC curves and the area under the curve (AUCs) via bootstrap method were used to analyse the prognostic impact of various inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic immune-inflammation index (SII) and prognostic nutrition index (PNI).
A total of 768 patients were enrolled for analysis. In univariate analysis, right-sided colon cancer (RCC) patients have significantly higher mean levels of all inflammatory markers than left-sided colon cancer (LCC) patients. In multivariate analyses, high NLR in LCC (P = 0.025) and low PNI in both RCC (P = 0.049) and LCC (P = 0.027) were significantly associated with a worse OS while none of the inflammatory markers was found to have a significant impact on DFS or CSS.
The profiles and prognostic impact of inflammatory markers are significantly different between stage II RCC and LCC patients. Researchers should take sidedness into consideration when addressing survival analysis of inflammatory markers.
越来越多的证据表明炎症标志物与结直肠癌的肿瘤学结果之间存在高度相关性。本研究旨在评估五种炎症标志物在不同肿瘤部位的 II 期结肠癌患者中的预后价值。
回顾性分析连续接受根治性切除术的 II 期结肠腺癌患者。通过 bootstrap 方法绘制 ROC 曲线和曲线下面积（AUCs），分析包括中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、淋巴细胞与单核细胞比值（LMR）、全身免疫炎症指数（SII）和预后营养指数（PNI）在内的各种炎症标志物的预后影响。
共纳入 768 例患者进行分析。在单因素分析中，右半结肠癌（RCC）患者的所有炎症标志物的平均水平均显著高于左半结肠癌（LCC）患者。多因素分析显示，LCC 中 NLR 较高（P=0.025）和 RCC 及 LCC 中 PNI 较低（P=0.049 和 P=0.027）与 OS 较差显著相关，而其他炎症标志物均与 DFS 或 CSS 无显著相关性。
II 期 RCC 和 LCC 患者的炎症标志物特征和预后影响显著不同。研究人员在进行炎症标志物生存分析时应考虑肿瘤侧别。
