Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Institute of Respiratory Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Int J Chron Obstruct Pulmon Dis. 2022 Sep 6;17:2117-2125. doi: 10.2147/COPD.S368543. eCollection 2022.
The mechanism of lung cancer (LC) in male patients with chronic obstructive pulmonary disease (COPD) has not been well understood, and the early diagnosis is currently challenging. The study aimed to explore the association of DNA methylation levels with LC development in male COPD patients.
A total of 147 male participants were divided into four groups, ie, COPD+LC group, COPD group, LC group, and control (CON) group. The methylation levels of human serine protease inhibitor A1 () and the serum levels of inflammatory biomarkers were compared among groups. Multivariate logistic regression was performed to explore the correlation of inflammatory biomarkers and gene methylation with lung cancer combining COPD.
methylation levels were significantly higher in the COPD+LC group than that in the COPD group and LC group, respectively (all 0.05). The serum levels of interleukin (IL)-1β, IL-17, and transforming growth factor (TGF)-β1 were significantly higher in the COPD+LC group than in the LC group (all 0.05). The methylation levels were positively correlated with the IL-1β levels (r = 0.5188, = 0.0012). The AUC (area under curve) of methylation for the diagnosis of LC in COPD was 0.677 (sensitivity of 52.2% and specificity of 78.2%).
The methylation of is linked to LC in patients with COPD. The methylation levels were positively correlated with the IL-1β levels. These findings may be of diagnostic value.
男性慢性阻塞性肺疾病（COPD）患者肺癌（LC）的发病机制尚不清楚，目前早期诊断具有挑战性。本研究旨在探讨 DNA 甲基化水平与男性 COPD 患者 LC 发展的关系。
共纳入 147 名男性参与者，分为 COPD+LC 组、COPD 组、LC 组和对照组（CON）。比较各组人丝氨酸蛋白酶抑制剂 A1（）的甲基化水平和血清炎症生物标志物水平。采用多变量 logistic 回归分析炎症生物标志物和基因甲基化与合并 COPD 的肺癌的相关性。
COPD+LC 组的甲基化水平明显高于 COPD 组和 LC 组（均 0.05）。COPD+LC 组血清白细胞介素（IL）-1β、IL-17 和转化生长因子（TGF）-β1 水平明显高于 LC 组（均 0.05）。甲基化水平与 IL-1β水平呈正相关（r = 0.5188， = 0.0012）。 甲基化用于诊断 COPD 合并 LC 的 AUC（曲线下面积）为 0.677（灵敏度为 52.2%，特异性为 78.2%）。
COPD 患者中 的甲基化与 LC 相关。甲基化水平与 IL-1β水平呈正相关。这些发现可能具有诊断价值。
