威尔逊病中的自身抗体：对临床病程的影响。
Autoantibodies in Wilson disease: Impact on clinical course.
作者信息
Antczak-Kowalska Magdalena, Członkowska Anna, Eyileten Ceren, Palejko Anna, Cudna Agnieszka, Wolska Marta, Piechal Agnieszka, Litwin Tomasz
机构信息
2nd Department of Neurology Institute of Psychiatry and Neurology Warsaw Poland.
Center for Preclinical Research and Technology CEPT, Department of Experimental and Clinical Pharmacology Medical University of Warsaw Warsaw Poland.
出版信息
JIMD Rep. 2022 Jul 22;63(5):508-517. doi: 10.1002/jmd2.12317. eCollection 2022 Sep.
Symptoms of Wilson disease (WD) vary and additional factors such as autoimmunity may play an important role in WD pathogenesis. The presence of antinuclear antibodies (ANA), anti-neutrophil cytoplasmic antibodies, neuronal surface antibodies, and onconeural antibodies in WD was investigated using standardized indirect immunofluorescence assays and Western Blot analysis. The presence of all studied autoantibodies was higher in WD patients in comparison to healthy subjects, but there was no statistically significant difference in autoantibodies frequency according to disease manifestation. D-penicillamine treatment was associated with a higher presence of ANA than zinc sulfate but without an increase in autoimmune diseases rate.
威尔逊病（WD）的症状各不相同，自身免疫等其他因素可能在WD发病机制中起重要作用。采用标准化间接免疫荧光试验和蛋白质印迹分析，对WD患者中抗核抗体（ANA）、抗中性粒细胞胞浆抗体、神经元表面抗体和肿瘤相关神经元抗体的存在情况进行了研究。与健康受试者相比，WD患者中所有研究的自身抗体的存在率更高，但根据疾病表现，自身抗体频率无统计学显著差异。与硫酸锌相比，D-青霉胺治疗与更高的ANA存在率相关，但自身免疫性疾病发生率并未增加。
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