双齿喹啉配体 -Mn(CO) 配合物对三阴性乳腺癌的细胞毒性。
Cytotoxicity of -Mn(CO) complexes with a bidentate quinoline ligand towards triple negative breast cancer.
机构信息
Department of Pharmacology, Toxicology and Clinical Pharmacy, German University in Cairo, New Cairo, Egypt.
Department of Chemistry, Faculty of Science, Cairo University, Gamma Street, Giza, Cairo 12613, Egypt.
出版信息
Dalton Trans. 2022 Sep 26;51(37):14041-14048. doi: 10.1039/d2dt01938h.
The cytotoxicity of two tricarbonyl Mn(I) complexes of the general formula -[MnBr(CO)L] (L = quinoline-2-carboxaldehyde (A) and 8-amino quinoline (B)) towards triple negative breast cancer (MDA-MB-231) was reported. Complexes A and B released CO when exposed to 468 nm light. Compound B has a dose-dependent cytotoxicity, with half maximal inhibitory concentration values of 19.62 μM and 11.43 μM before and after illumination, respectively. Co-treatment of MDA-MB-231 with paclitaxel (30 nM) and complex B (10 μM) resulted in a 50% reduction in cell viability.
报道了两种三羰基锰（I）配合物的细胞毒性，它们的通式为-[MnBr(CO)L]（L=喹啉-2-甲醛（A）和 8-氨基喹啉（B）），针对三阴性乳腺癌（MDA-MB-231）。配合物 A 和 B 在暴露于 468nm 光时会释放 CO。化合物 B 具有剂量依赖性的细胞毒性，在照射前后的半最大抑制浓度值分别为 19.62 μM 和 11.43 μM。MDA-MB-231 与紫杉醇（30 nM）和配合物 B（10 μM）共同处理，导致细胞活力降低 50%。
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