Nibbio Gabriele, Barlati Stefano, Calzavara-Pinton Irene, Necchini Nicola, Invernizzi Elena, Dell'Ovo Dario, Lisoni Jacopo, Deste Giacomo, Vita Antonio
Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy.
Front Psychiatry. 2022 Aug 30;13:934005. doi: 10.3389/fpsyt.2022.934005. eCollection 2022.
Schizophrenia Spectrum Disorders (SSD) and Autism Spectrum Disorders (ASD) are considered separate entities, but the two spectra share important similarities, and the study of these areas of overlap represents a field of growing scientific interest. The PANSS Autism Score (PAUSS) was recently developed specifically to assess autistic symptoms in people living with SSD reliably and quickly. The aims of the present systematic review were to provide a comprehensive assessment of the use of the PAUSS scale in available literature and to systematically analyze cognitive, functional and neurobiological correlates of autistic symptoms measured with this instrument in SSD. The systematic literature search included three electronic databases (PubMed, Scopus and PsycINFO) as well as a manual search in Google Scholar and in reference lists of included papers. Screening and extraction were conducted by at least two independent reviewers. Out of 213 identified records, 22 articles referring to 15 original studies were included in the systematic review. Studies were conducted in several different countries by independent groups, showing consistent scientific interest in the use of the scale; most works focused on cognitive and functional correlates of ASD symptoms, but some also considered neurobiological features. Results of included studies showed that autistic symptoms in people with SSD are consistently associated with worse cognitive performance, especially in the social cognition domain, and with worse psychosocial functioning. However, the presence of autistic symptoms appears to also have a protective role, particularly on functioning, in subjects with more severe psychotic symptoms. Further exploring the impact of autistic symptoms could be of significant scientific and clinical interest, allowing the development of tailored interventions to improve treatment for people living with SSDs.
精神分裂症谱系障碍（SSD）和自闭症谱系障碍（ASD）被视为不同的疾病实体，但这两个谱系存在重要的相似之处，对这些重叠领域的研究是一个日益受到科学界关注的领域。PANSS自闭症评分（PAUSS）最近专门开发出来，用于可靠、快速地评估SSD患者的自闭症症状。本系统评价的目的是全面评估PAUSS量表在现有文献中的使用情况，并系统分析用该工具测量的SSD患者自闭症症状的认知、功能和神经生物学相关性。系统文献检索包括三个电子数据库（PubMed、Scopus和PsycINFO）以及在谷歌学术和纳入论文的参考文献列表中的手动检索。筛选和提取由至少两名独立审稿人进行。在确定的213条记录中，有22篇文章涉及15项原始研究被纳入系统评价。独立研究小组在几个不同国家开展了研究，表明对该量表的使用存在持续的科学兴趣；大多数研究关注ASD症状的认知和功能相关性，但也有一些研究考虑了神经生物学特征。纳入研究的结果表明，SSD患者的自闭症症状始终与较差的认知表现相关，尤其是在社会认知领域，并且与较差的社会心理功能相关。然而，自闭症症状的存在似乎在症状更严重的精神分裂症患者中也具有保护作用，特别是在功能方面。进一步探索自闭症症状的影响可能具有重大的科学和临床意义，有助于开发针对性的干预措施，以改善对SSD患者的治疗。
