Genetic polymorphism of clopidogrel metabolism related gene gene in Chinese from Foshan area of Guangdong Province.

BACKGROUND

The gene is highly polymorphic, and is involved in the broad interindividual variability of the clinical efficacy of certain clinical medications, such as clopidogrel. However, data on the genotype in the Chinese population of the Foshan area of Guangdong Province are scarce. The purpose of this study was to determine genetic polymorphisms in patients in the Foshan area and to compare the genotype frequencies in different populations to determine the allele distribution pattern to identify the most appropriate prescription.

METHODS

The gene was detected in 1231 patients on a gene chip platform, and the genotype frequencies of in Foshan populations from different populations were compared.

RESULTS

The frequencies of , and in the Foshan population were 63.89%, 30.46% and 5.65%, respectively. For the three metabolic types, the frequency associated with the rapid metabolism type () was 41.51 [95% confidence interval (CI) 40.11 to 42.91%]; that for the intermediate metabolism type () was 44.76% (95% CI 43.34 to 46.18) and that for the slow metabolism type ) was 13.73% (95% CI 12.75 to 14.71%). In the Foshan population, the frequencies of the and alleles were similar to those previously reported for Chinese and other Asian populations.

CONCLUSION

Our study is a report on the genetic basis of polymorphism in the Foshan population. Our results will potentially contribute to the improvement of pharmacotherapy effectiveness by providing personalized medicine for the Foshan population.