一级亲属胃癌筛查：多元化综合医疗体系中的试点研究。
Gastric Cancer Screening in First-Degree Relatives: A Pilot Study in a Diverse Integrated Healthcare System.
机构信息
Division of Gastroenterology, Southern California Permanente Medical Group, Los Angeles, California, USA.
Division of Gastroenterology, Southern California Permanente Medical Group, Anaheim, California, USA.
出版信息
Clin Transl Gastroenterol. 2022 Nov 1;13(11):e00531. doi: 10.14309/ctg.0000000000000531.
INTRODUCTION
Family history of gastric cancer has been shown as an independent risk factor of gastric cancer development and is associated with increased risk of progression to gastric cancer among patients with gastric intestinal metaplasia (GIM).
METHODS
Between 2017 and 2020, we conducted a prospective pilot screening program of patients with a confirmed first-degree relative with gastric cancer to evaluate the feasibility of screening and prevalence of precursor lesions (e.g., GIM or dysplasia) on biopsy.
RESULTS
A total of 61 patients completed screening by upper endoscopy with a mapping biopsy protocol: 27 (44%) were found to have GIM and 4 (7%) were found with low-grade dysplasia.
DISCUSSION
Our pilot screening program identified a high prevalence of precursor lesions for gastric cancer among asymptomatic patients with a first-degree relative with gastric cancer. Careful endoscopic inspection and standardized biopsy protocols may aid in prompt identification of these precursor lesions in those at risk of gastric cancer.
简介
胃癌家族史已被证明是胃癌发展的独立危险因素，并且与胃黏膜肠上皮化生（GIM）患者胃癌进展的风险增加相关。
方法
在 2017 年至 2020 年期间，我们开展了一项针对有确诊一级亲属患有胃癌的患者的前瞻性试点筛查计划，以评估筛查的可行性和活检前病变（如 GIM 或异型增生）的患病率。
结果
共有 61 名患者通过上消化道内镜检查和图谱活检方案完成了筛查：27 名（44%）患者发现有 GIM，4 名（7%）患者发现有低级别异型增生。
讨论
我们的试点筛查计划在有一级亲属患有胃癌的无症状患者中发现了胃癌前病变的高患病率。仔细的内镜检查和标准化的活检方案可能有助于及时识别这些高危人群中的胃癌前病变。
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