环状RNA/长链非编码RNA-微小RNA-信使RNA轴在胃癌中的研究进展

Research progress on the circRNA/lncRNA-miRNA-mRNA axis in gastric cancer.

作者信息

Zeng Xuemei, Xiao Juan, Bai Xue, Liu Yiwen, Zhang Meilan, Liu Jiangrong, Lin Zixuan, Zhang Zhiwei

机构信息

Cancer Research Institute of Hengyang Medical School, University of South China; Key Laboratory of Cancer Cellular and Molecular Pathology in Hunan Province, Hengyang, Hunan 421001, China.

Department of Otorhinolaryngology, The Second Affiliated Hospital, Hengyang Medical School,University of South China, Hengyang 421001, China.

出版信息

Pathol Res Pract. 2022 Oct;238:154030. doi: 10.1016/j.prp.2022.154030. Epub 2022 Jul 19.

DOI:10.1016/j.prp.2022.154030

PMID:36116329

Abstract

Gastric cancer is one of the most common malignant tumours worldwide. Genetic and epigenetic alterations are key factors in gastric carcinogenesis and drug resistance to chemotherapy. Competing endogenous RNA (ceRNA) regulation models have defined circRNA/lncRNA as miRNA sponges that indirectly regulate miRNA downstream target genes. The ceRNA regulatory network is related to the malignant biological behaviour of gastric cancer. The circRNA/lncRNA-miRNA-mRNA axis may be a marker for the early diagnosis and prognosis of gastric cancer and a potential therapeutic target for gastric cancer. Exosomal ncRNAs play an important role in gastric cancer and are expected to be ideal biomarkers for the diagnosis, prognosis, and treatment of gastric cancer. This review summarizes the specific ceRNA regulatory network (circRNA/lncRNA-miRNA-mRNA) discovered in gastric cancer in recent years, which may provide new ideas or strategies for early clinical diagnosis, further development, and application.

摘要

胃癌是全球最常见的恶性肿瘤之一。基因和表观遗传改变是胃癌发生及化疗耐药的关键因素。竞争性内源RNA（ceRNA）调控模型将环状RNA（circRNA）/长链非编码RNA（lncRNA）定义为微小RNA（miRNA）海绵，间接调控miRNA下游靶基因。ceRNA调控网络与胃癌的恶性生物学行为相关。circRNA/lncRNA-miRNA-mRNA轴可能是胃癌早期诊断和预后的标志物以及胃癌潜在的治疗靶点。外泌体非编码RNA在胃癌中发挥重要作用，有望成为胃癌诊断、预后及治疗的理想生物标志物。本文综述了近年来在胃癌中发现的特定ceRNA调控网络（circRNA/lncRNA-miRNA-mRNA），可为临床早期诊断、进一步研发及应用提供新思路或策略。