Wang Haoran, Chen Boran, Cen Ying, Chen Junjie
Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu 61000, China.
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 61000, China.
J Oncol. 2022 Sep 8;2022:5735679. doi: 10.1155/2022/5735679. eCollection 2022.
The use of adjuvant radiotherapy (RT) for well-differentiated liposarcoma (WD-LPS) patients with positive surgical margins is unclear. We aim to compare the overall survival (OS) and cancer-specific survival (CSS) of well-differentiated liposarcoma patients with positive surgical margins in an RT group and non-RT group.
WD-LPS patients with positive margins from 2000 to 2018 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database and divided into two groups: RT group and non-RT group. Kaplan-Meier survival analysis with the log-rank test was performed to evaluate the difference of overall survival (OS) and cancer-specific survival (CSS) between groups. Univariate and multivariate Cox proportional hazard analyses were performed to identify important prognostic factors of OS and CSS. Analyses were adjusted using propensity-score matching.
We identified 2549 patients: 377 (14.79%) with RT and 2172 (85.21%) without RT. The median age was 61 years, and the median follow-up time was 68 months. The log-rank test revealed that there was no significant difference of CSS between RT and non-RT groups ( = 0.81). The 5-year and 10-year CSS were comparable ( = 0.418 and = 0.987). Additionally, the use of RT was neither an independent prognostic factor for OS nor CSS. Age, sex, tumor site, the use of chemotherapy were independent prognostic factors for OS after propensity score matching, while race and the tumor site were independent prognostic factors for CSS.
Adjuvant RT had no significant improvement on OS and CSS of WD-LPS patients with positive surgical margins.
对于手术切缘阳性的高分化脂肪肉瘤（WD-LPS）患者，辅助放疗（RT）的使用尚不清楚。我们旨在比较放疗组和非放疗组中手术切缘阳性的高分化脂肪肉瘤患者的总生存期（OS）和癌症特异性生存期（CSS）。
从监测、流行病学和最终结果（SEER）数据库中提取2000年至2018年手术切缘阳性的WD-LPS患者，并将其分为两组：放疗组和非放疗组。采用Kaplan-Meier生存分析和对数秩检验来评估两组之间总生存期（OS）和癌症特异性生存期（CSS）的差异。进行单因素和多因素Cox比例风险分析，以确定OS和CSS的重要预后因素。分析采用倾向评分匹配进行调整。
我们共纳入2549例患者：377例（14.79%）接受放疗，2172例（85.21%）未接受放疗。中位年龄为61岁，中位随访时间为68个月。对数秩检验显示，放疗组和非放疗组之间的CSS无显著差异（ = 0.81）。5年和10年的CSS具有可比性（ = 0.418和 = 0.987）。此外，放疗的使用既不是OS也不是CSS的独立预后因素。倾向评分匹配后，年龄、性别、肿瘤部位、化疗的使用是OS的独立预后因素，而种族和肿瘤部位是CSS的独立预后因素。
辅助放疗对手术切缘阳性的WD-LPS患者的OS和CSS没有显著改善。
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