急诊出口处承受着压力。
ER exit sites take the strain.
机构信息
Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.
University of Naples "Federico II", Naples, Italy.
出版信息
EMBO J. 2022 Nov 2;41(21):e112349. doi: 10.15252/embj.2022112349. Epub 2022 Sep 19.
Abstract
Cells are able to adapt their growth to external mechanical strain. A recent study by Phuyal et al (2022) has shown that these responses depend on the heterodimerization of two small GTPases.
摘要
细胞能够适应外部机械应变来调整其生长。最近由 Phuyal 等人（2022 年）进行的一项研究表明，这些反应取决于两种小 GTPases 的异二聚化。
相似文献
1
ER exit sites take the strain.
EMBO J. 2022 Nov 2;41(21):e112349. doi: 10.15252/embj.2022112349. Epub 2022 Sep 19.
2
[Roles of small GTPases and BAR domain proteins in post-Golgi membrane traffic].
Seikagaku. 2012 Sep;84(9):785-90.
3
Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells.
Traffic. 2006 Dec;7(12):1678-87. doi: 10.1111/j.1600-0854.2006.00493.x. Epub 2006 Sep 27.
4
Anterograde trafficking of nascent α(2B)-adrenergic receptor: structural basis, roles of small GTPases.
Curr Top Membr. 2011;67:79-100. doi: 10.1016/B978-0-12-384921-2.00004-5.
5
Conditional inactivation of Aspergillus nidulans sarA(SAR1) uncovers the morphogenetic potential of regulating endoplasmic reticulum (ER) exit.
Mol Microbiol. 2015 Feb;95(3):491-508. doi: 10.1111/mmi.12880. Epub 2014 Dec 30.
6
Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum.
Nat Cell Biol. 1999 Nov;1(7):423-30. doi: 10.1038/15658.
7
Maintenance of Golgi structure and function depends on the integrity of ER export.
J Cell Biol. 2001 Nov 12;155(4):557-70. doi: 10.1083/jcb.200107045.
8
p125 is localized in endoplasmic reticulum exit sites and involved in their organization.
J Biol Chem. 2005 Mar 18;280(11):10141-8. doi: 10.1074/jbc.M409673200. Epub 2004 Dec 28.
9
COPII proteins are required for Golgi fusion but not for endoplasmic reticulum budding of the pre-chylomicron transport vesicle.
J Cell Sci. 2003 Jan 15;116(Pt 2):415-27. doi: 10.1242/jcs.00215.
10
Post-Golgi protein traffic in the plant secretory pathway.
Plant Cell Rep. 2007 Sep;26(9):1431-8. doi: 10.1007/s00299-007-0390-z. Epub 2007 Jun 6.
本文引用的文献
1
Mechanical strain stimulates COPII-dependent secretory trafficking via Rac1.
EMBO J. 2022 Sep 15;41(18):e110596. doi: 10.15252/embj.2022110596. Epub 2022 Aug 8.
2
Regulation of the COPII secretory machinery via focal adhesions and extracellular matrix signaling.
J Cell Biol. 2022 Aug 1;221(8). doi: 10.1083/jcb.202110081. Epub 2022 Jul 13.
3
A tango for coats and membranes: New insights into ER-to-Golgi traffic.
Cell Rep. 2022 Jan 18;38(3):110258. doi: 10.1016/j.celrep.2021.110258.
4
Focused Ultrasound Stimulates ER Localized Mechanosensitive PANNEXIN-1 to Mediate Intracellular Calcium Release in Invasive Cancer Cells.
Front Cell Dev Biol. 2020 Jun 23;8:504. doi: 10.3389/fcell.2020.00504. eCollection 2020.
5
Small sequence variations between two mammalian paralogs of the small GTPase SAR1 underlie functional differences in coat protein complex II assembly.
J Biol Chem. 2020 Jun 19;295(25):8401-8412. doi: 10.1074/jbc.RA120.012964. Epub 2020 May 1.
6
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.
Nat Cell Biol. 2020 Apr;22(4):498-511. doi: 10.1038/s41556-020-0488-x. Epub 2020 Mar 23.
7
Crosstalk of endoplasmic reticulum exit sites and cellular signaling.
FEBS Lett. 2019 Sep;593(17):2280-2288. doi: 10.1002/1873-3468.13569. Epub 2019 Aug 12.
8
Auto-regulation of Secretory Flux by Sensing and Responding to the Folded Cargo Protein Load in the Endoplasmic Reticulum.
Cell. 2019 Mar 7;176(6):1461-1476.e23. doi: 10.1016/j.cell.2019.01.035.
9
Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP.
Nat Cell Biol. 2019 Mar;21(3):338-347. doi: 10.1038/s41556-018-0270-5. Epub 2019 Feb 4.
10
Compartmentalisation of RAC1 signalling.
Curr Opin Cell Biol. 2018 Oct;54:50-56. doi: 10.1016/j.ceb.2018.04.009. Epub 2018 Apr 30.
Zotero 插件