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[首剂抗SARS-CoV-2 mRNA疫苗接种后卡介苗接种部位瘢痕的炎症反应]

[Inflammation of BCG Inoculation Site Scar after the First Dose of an Anti-SARS-CoV-2 mRNA Vaccine].

作者信息

Barros Rodrigues João, Pacheco Maria, Antunes Ivan, Sousa Ricardo

机构信息

Serviço de Medicina Interna. Unidade Local de Saúde da Guarda. Guarda. Portugal.

Serviço de Medicina Geral e Familiar. Unidade de Saúde Familiar de Terras do Souza. Paredes. Portugal.

出版信息

Acta Med Port. 2023 Jul 3;36(7-8):511-514. doi: 10.20344/amp.16971. Epub 2022 Sep 19.

Abstract

Inflammatory reactions in the Bacillus Calmette-Guérin (BCG) inoculation scar site have been previously described, in association with viral infections. The inflammation of the scar in association with other vaccines has been described with the flu vaccine and, more recently, after the second dose of mRNA anti-SARS-CoV-2 vaccines (mRNA-1273 e BNT162b2), in two healthcare workers. We present the case of a 27-year-old female, without a relevant past medical history, including no previous SARS-CoV-2 infection, and with inflammation of the BCG scar eight days after the first dose of the mRNA anti-SARS-CoV-2 vaccine. Pharmacovigilance and the notification of adverse events should be encouraged, as a way of warding off hesitation in this process.

摘要

卡介苗(BCG)接种疤痕部位的炎症反应此前已有报道,与病毒感染有关。流感疫苗接种后以及最近在两名医护人员接种第二剂mRNA抗SARS-CoV-2疫苗(mRNA-1273和BNT162b2)后,也出现了与其他疫苗相关的疤痕炎症。我们报告了一例27岁女性病例,她既往无相关病史,包括未曾感染过SARS-CoV-2,在接种第一剂mRNA抗SARS-CoV-2疫苗八天后出现卡介苗疤痕炎症。应鼓励开展药物警戒和不良事件报告,以避免在此过程中出现犹豫。

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