在离体龟视觉系统中，皮层锥体神经元对光刺激的突触反应。
Synaptic responses of cortical pyramidal neurons to light stimulation in the isolated turtle visual system.
作者信息
Kriegstein A R
出版信息
J Neurosci. 1987 Aug;7(8):2488-92.
Abstract
The resistance of the turtle brain to hypoxic injury permits a unique in vitro preparation in which the organization and function of visual cortex can be explored. Intracellular recordings from cortical pyramidal neurons revealed biphasic responses to flashes of light, consisting of an early phase (50-100 msec) of concurrent inhibitory and excitatory activation, followed by a longer, inhibitory phase (250-600 msec) composed of summated Cl- -dependent postsynaptic potentials mediated by GABA. This response sequence results from the coactivation of pyramidal and GABAergic non-pyramidal cells, followed by feed-forward and possibly feed-back pyramidal cell inhibition, and is partly dependent on differences in the membrane properties of pyramidal and non-pyramidal neurons.
摘要
龟脑对缺氧损伤的耐受性使得一种独特的体外制备方法成为可能，借此可以探究视觉皮层的组织结构和功能。对皮层锥体神经元进行的细胞内记录显示，对光闪烁有双相反应，包括一个早期阶段（50 - 100毫秒），同时存在抑制性和兴奋性激活，随后是一个较长的抑制阶段（250 - 600毫秒），该阶段由GABA介导的总和Cl⁻依赖性突触后电位组成。这种反应序列源于锥体神经元和GABA能非锥体神经元的共同激活，随后是前馈以及可能的反馈性锥体神经元抑制，并且部分取决于锥体神经元和非锥体神经元膜特性的差异。
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