Romanos George N, Volioti Areti V, Hatzimanolis Panagiotis I, Koutserimpas Christos, Samonis George
Department of Oral and Maxillofacial Surgery, University Hospital of Heraklion.
Department of Orthopaedics and Traumatology, "251" Hellenic Air Force General Hospital.
Kurume Med J. 2022 Nov 16;67(2.3):107-112. doi: 10.2739/kurumemedj.MS6723004. Epub 2022 Sep 16.
Bisphosphonate-related osteonecrosis of the jaws represents a well-recognized complication occurring in patients being administered drugs for the treatment of osteoporosis and/or malignant disease. Treatment of this condition, aiming to alleviate the symptoms and restore functional status, represents a challenge for the maxillofacial surgeon. Conservative management has been proposed for early stages of this condition, while surgical intervention is mandatory for advanced disease. Two cases of severe bisphosphonate-related osteonecrosis of the jaw that achieved complete osseous recontouring after partial mandibulectomy, are presented.
双膦酸盐相关的颌骨坏死是一种在接受治疗骨质疏松症和/或恶性疾病药物的患者中出现的广为人知的并发症。针对这种情况的治疗旨在缓解症状并恢复功能状态,这对颌面外科医生来说是一项挑战。对于该病症的早期阶段,已有人提出采用保守治疗,而对于晚期疾病则必须进行手术干预。本文介绍了两例严重的双膦酸盐相关颌骨坏死病例,这两例患者在接受部分下颌骨切除术后实现了完全的骨轮廓重塑。