通过硫代里特型反应由烷基溴化物、腈和硫化氢制备硫代酰胺。
Preparation of thioamides from alkyl bromides, nitriles, and hydrogen sulfide through a thio-Ritter-type reaction.
机构信息
State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.
Beijing Key Laboratory of Research and Application for Aerospace Green Propellants, Beijing Institute of Aerospace Testing Technology, Beijing 100074, China.
出版信息
Chem Commun (Camb). 2022 Oct 11;58(81):11430-11433. doi: 10.1039/d2cc04210j.
A novel thio-Ritter-type reaction of alkyl bromides, nitriles, and hydrogen sulfide has been explored, providing a straightforward approach toward functionally important thioamides. This transformation features a broad substrate scope, operational simplicity, use of available feedstock chemicals, and late-stage functionalizations of bioactive molecules. The reaction mechanism is also proposed.
一种新型的溴代烷基、腈和硫化氢的硫里特型反应已经被探索出来，为具有重要功能的硫代酰胺提供了一种直接的方法。这种转化具有广泛的底物范围、操作简单、使用可用的原料化学品以及生物活性分子的后期功能化等特点。还提出了反应机制。
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