Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina, Tubarao, SC, Brazil.
Laboratory of Experimental Neurology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, SC, Brazil.
Mol Neurobiol. 2022 Dec;59(12):7229-7235. doi: 10.1007/s12035-022-03027-7. Epub 2022 Sep 22.
Sepsis is a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. Surviving patients have cognitive and memory damage that started during sepsis. These neurologic damages have been associated with increased BBB permeability and microglial activation. However, a few discrete studies have seen over the years pointing to the potential role of astrocytes in the pathophysiology of neurological damage after sepsis. The purpose of this article is to review information on the potential role of astrocytes during sepsis, as well as to provoke further studies in this area. These published articles show astrocytic activation after sepsis; they also evidence the release of inflammatory mediators by these cells. In this sense, the role of astrocytes should be better elucidated during sepsis progression.
败血症是一种危及生命的器官功能障碍，是由宿主对感染的失调反应引起的。幸存的患者在败血症期间出现认知和记忆损伤。这些神经损伤与 BBB 通透性增加和小胶质细胞激活有关。然而，多年来，一些离散的研究表明星形胶质细胞在败血症后神经损伤的病理生理学中可能发挥作用。本文的目的是综述败血症期间星形胶质细胞的潜在作用，并在此领域引发进一步的研究。这些已发表的文章表明败血症后星形胶质细胞的激活；它们还证明了这些细胞释放炎症介质。从这个意义上说，在败血症的进展过程中，星形胶质细胞的作用应该得到更好的阐明。
