一名结肠癌患者血管免疫母细胞性T细胞淋巴瘤所致淋巴结病中镓标记的纤维连接蛋白拮抗剂（Ga-FAPI）和氟代脱氧葡萄糖（F-FDG）的不同摄取情况
Different Uptake of Ga-FAPI and F-FDG in Lymphadenopathy Caused by Angioimmunoblastic T-Cell Lymphoma in a Patient with Colon Cancer.
作者信息
Wu Meiqi, Pan Qingqing, Luo Yaping
机构信息
Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China.
Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China.
出版信息
Diagnostics (Basel). 2022 Sep 13;12(9):2211. doi: 10.3390/diagnostics12092211.
An 82-year-old man with a history of colon cancer was found with multiple lymphadenopathies and a pulmonary mass. Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) detected generalized hypermetabolic lymph nodes and an FDG-avid pulmonary mass. PET/CT with Ga-labeled fibroblast activation protein inhibitor (FAPI) revealed intense uptake in the lung mass, consistent with metastatic disease from colon cancer. However, the lymphadenopathies were not avid for Ga-FAPI, suggesting a different etiology. The biopsy of a cervical node confirmed angioimmunoblastic T-cell lymphoma. The case showcased the potential of Ga-FAPI in differentiation of solid tumor and hematological disease due to different histopathologic nature of stromal fibrosis.
一名有结肠癌病史的82岁男性被发现有多处淋巴结肿大和肺部肿块。氟-18氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）检测到全身代谢亢进的淋巴结和一个FDG摄取阳性的肺部肿块。使用镓标记的成纤维细胞活化蛋白抑制剂（FAPI）的PET/CT显示肺部肿块有强烈摄取，符合结肠癌转移灶。然而，淋巴结肿大对镓-FAPI摄取不明显，提示病因不同。颈部淋巴结活检证实为血管免疫母细胞性T细胞淋巴瘤。该病例展示了由于基质纤维化的组织病理学性质不同，镓-FAPI在鉴别实体瘤和血液系统疾病方面的潜力。
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