Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Department of Gastroenterology, Emergency Clinical County Hospital, 400006 Cluj-Napoca, Romania.
Int J Mol Sci. 2022 Sep 8;23(18):10351. doi: 10.3390/ijms231810351.
Neuroendocrine tumors (NEN) are a type of heterogenous, slow-growing tumors, that only in about half of the cases can be found in the gastrointestinal tract. Half of these is in the small intestine. The ampullary NENs are rare, accounting for less than 1% of gastroenteropancreatic NENs. Gastrointestinal stromal tumors (GIST) are a more common type of tumors of the gastrointestinal tract that consist of pacemaker cells. The occurrence of both tumors simultaneously is rare, but in patients with neurofibromatosis type 1, the co-existence of NEN and GIST is more often. Here we report a case of simultaneous occurrence of a well-differentiated NEN and a GIST in a patient without neurofibromatosis. Also, we provide a short review of the current knowledge and treatment strategies regarding these tumors.
神经内分泌肿瘤（NEN）是一种异质性的、生长缓慢的肿瘤，仅约半数病例可在胃肠道中发现。其中一半发生在小肠。壶腹神经内分泌肿瘤较为罕见，占胃肠胰神经内分泌肿瘤的不到 1%。胃肠道间质瘤（GIST）是胃肠道中更常见的肿瘤类型，由起搏细胞组成。这两种肿瘤同时发生的情况较为罕见，但在神经纤维瘤病 1 型患者中，NEN 和 GIST 同时存在的情况更为常见。本文报告了一例无神经纤维瘤病的患者同时发生分化良好的 NEN 和 GIST 的病例。此外，我们还对这些肿瘤的现有知识和治疗策略进行了简要回顾。
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