Ugolev A M, Gruzdkov A A, Zil'ber Iu D, Iezuitova N N, Timofeeva N M
Fiziol Zh SSSR Im I M Sechenova. 1978 Sep;64(9):1217-28.
In rats fed for 4, 15, and 30 days with increased amount of proteins, lipids, and carbohydrates, considerable shifts occurred in activity of enzymes of the pancreas (amylase, protease, and lipase) and small intestine (gamma--amylase, maltase group, invertase, peptidhydrolase, monoglyceriflipase). Mathematical analysis suggested a close connection between the adaptive shifts in the enzyme systems maintaining the lumen and the membrane types of digestion. The protein diet augments the proteolytic enzyme chain the lipid diet--the lipolytic chain, and the carbohydrate diet--the carbohydrate chain. The shifts should be regarded as an integrative adaptive response of the enzyme spectrum of the pancreas and small intestine to alterations in the food composition.
给大鼠分别喂食富含蛋白质、脂质和碳水化合物的饲料4天、15天和30天，胰腺（淀粉酶、蛋白酶和脂肪酶）和小肠（γ-淀粉酶、麦芽糖酶组、转化酶、肽水解酶、甘油单酯脂肪酶）的酶活性发生了显著变化。数学分析表明，维持管腔和膜消化类型的酶系统的适应性变化之间存在密切联系。蛋白质饮食增强了蛋白水解酶链，脂质饮食增强了脂解酶链，碳水化合物饮食增强了碳水化合物酶链。这些变化应被视为胰腺和小肠酶谱对食物成分改变的一种综合适应性反应。
