Sarfraz Sonia, Mäntynen Pilvi-Helinä, Laurila Marisa, Rossi Sami, Leikola Junnu, Kaakinen Mika, Suojanen Juho, Reunanen Justus
Biocenter Oulu & Cancer and Translational Medicine Research Unit, University of Oulu, 90014 Oulu, Finland.
Päijät-Häme Joint Authority for Health and Wellbeing, Department of Oral and Maxillofacial Surgery, Lahti Central Hospital, 15850 Lahti, Finland.
Polymers (Basel). 2022 Sep 15;14(18):3862. doi: 10.3390/polym14183862.
This study investigated two of the most commonly used CAD-CAM materials for patient-specific reconstruction in craniomaxillofacial surgery. The aim of this study was to access the biofilm formation of , , , and on titanium and PEEK medical implant materials. Two titanium specimens (titanium grade 2 tooled with a Planmeca CAD-CAM milling device and titanium grade 5 tooled with a computer-aided design direct metal laser sintering device (CAD-DMLS)) and one PEEK specimen tooled with a Planmeca CAD-CAM milling device were studied. Bacterial adhesion on implants was evaluated in two groups (saliva-treated group and non-saliva-treated group) to imitate intraoral and extraoral surgical routes for implant placement. The PEEK medical implant material showed higher bacterial adhesion by , , and than titanium grade 2 and titanium grade 5, whereas showed higher adhesion to titanium as compared to PEEK. Saliva contamination of implants also effected bacterial attachment. Salivary coating enhanced biofilm formation by , , and . In conclusion, our findings imply that regardless of the implant material type or tooling techniques used, salivary coating plays a vital role in bacterial adhesion. In addition, the majority of the bacterial strains showed higher adhesion to PEEK than titanium.
本研究调查了颅颌面外科中用于患者特异性重建的两种最常用的计算机辅助设计与制造(CAD-CAM)材料。本研究的目的是评估 、 、 和 在钛及聚醚醚酮(PEEK)医用植入材料上的生物膜形成情况。研究了两个钛样本(一个是用普兰梅卡CAD-CAM铣削设备加工的2级钛,另一个是用计算机辅助设计直接金属激光烧结设备(CAD-DMLS)加工的5级钛)以及一个用普兰梅卡CAD-CAM铣削设备加工的PEEK样本。在两组(唾液处理组和非唾液处理组)中评估植入物上的细菌黏附情况,以模拟植入物放置的口腔内和口腔外手术路径。与2级钛和5级钛相比,PEEK医用植入材料被 、 和 黏附的细菌更多,而 与PEEK相比,对钛的黏附性更高。植入物的唾液污染也会影响细菌附着。唾液涂层增强了 、 和 的生物膜形成。总之,我们的研究结果表明,无论使用何种植入材料类型或加工技术,唾液涂层在细菌黏附中都起着至关重要的作用。此外,大多数细菌菌株对PEEK的黏附性高于钛。