长效注射抗精神病药与精神分裂症患者照料者负担、生活质量、症状严重程度和治疗中断的关系。
Relationship of Long Acting Injectable Antipsychotics with Caregiver Burden, Quality of Life, Symptom Severity and Treatment Discontinuation in Schizophrenia.
出版信息
Turk Psikiyatri Derg. 2022 Fall;33(3):167-179. doi: 10.5080/u26066.
OBJECTIVE
Regarding the patients using long acting injectable (LAI) antipsychotic treatment; we aimed to investigate the effect of attitude towards drugs, antipsychotic type and side effects on quality of life, caregiver burden and continuation of treatment.
METHOD
Our study sample consisted of 110 patients in the age range of 18-65 using LAI antipsychotics for at least 12 weeks with the diagnosis of schizophrenia according to DSM-5 criteria. Sociodemographic and Clinical Data Form, Drug Attitude Inventory 10 (DAI-10), Positive and Negative Syndrome Scale (PANSS), UKU Side Effect Rating Scale, Quality of Life for Schizophrenia Scale were used for evaluation of patients. Sociodemographic Data Form, Zarit Caregiver Burden Scale (ZCBS) were used for the caregivers.
RESULTS
It is observed that the patients with positive attitude against the treatment had longer antipsychotic treatment duration (13.7+9.1 years) compared to patients with negative attitude (7.7 + 6.6 years) (p<0.001). PANSS total scores of patients who were considering about treatment discontinuation (44.0+14.3) were higher than the other patients (38.6+9.0) (p=0.03) and DAI-10 scores of patients who were considering about treatment discontinuation were lower (1.4+4.9; 5.2+3.4; p<0.001). Duration of illness were also shorter (10.3+9.3 year) for the patients who were considering about treatment discontinuation than the other group (15.7 + 9.0 year) (p=0.01). There was no significant difference in caregiver burden, side effects, quality of life and reasons for treatment discontinuation between typical and atypical antipsychotics. According to the regression analysis results, PANSS score (β=0.553, p<0.001) and male gender (β= 0.225, p=0.003) were positive predictors of ZCBS scores.
CONCLUSION
It is observed that the attitude towards drugs and psychotic symptom severity were the most important factors for treatment discontinuation in patients with schizophrenia using LAI antipsychotics. Atypical and typical antipsychotics were not different with respect to quality of life and caregiver burden for the patients on regular treatment with LAI antipsychotics.
目的
对于使用长效注射（LAI）抗精神病药物治疗的患者，我们旨在研究药物态度、抗精神病药物类型和副作用对生活质量、照顾者负担和治疗延续性的影响。
方法
我们的研究样本包括 110 名年龄在 18-65 岁之间的患者，他们根据 DSM-5 标准诊断为精神分裂症，使用 LAI 抗精神病药物至少 12 周。使用药物态度量表 10 项（DAI-10）、阳性和阴性综合征量表（PANSS）、UKU 副作用量表、精神分裂症生活质量量表对患者进行评估。使用社会人口统计学数据表格和 Zarit 照顾者负担量表（ZCBS）对照顾者进行评估。
结果
结果表明，对治疗持积极态度的患者的抗精神病药物治疗持续时间（13.7+9.1 年）长于持消极态度的患者（7.7+6.6 年）（p<0.001）。考虑停药的患者的 PANSS 总分（44.0+14.3）高于其他患者（38.6+9.0）（p=0.03），考虑停药的患者的 DAI-10 评分较低（1.4+4.9；5.2+3.4；p<0.001）。考虑停药的患者的病程也较短（10.3+9.3 年），而其他组的病程较长（15.7+9.0 年）（p=0.01）。在典型和非典型抗精神病药物之间，照顾者负担、副作用、生活质量和停药原因方面没有显著差异。根据回归分析结果，PANSS 评分（β=0.553，p<0.001）和男性性别（β=0.225，p=0.003）是 ZCBS 评分的正预测因子。
结论
研究表明，对于使用 LAI 抗精神病药物治疗的精神分裂症患者，药物态度和精神病症状严重程度是停药的最重要因素。对于定期接受 LAI 抗精神病药物治疗的患者，典型和非典型抗精神病药物在生活质量和照顾者负担方面没有差异。
Zotero 插件