Copur Sidar, Ucku Duygu, Kanbay Mehmet
Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.
Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey.
Clin Kidney J. 2022 Jun 8;15(10):1800-1802. doi: 10.1093/ckj/sfac101. eCollection 2022 Oct.
Air pollution is an emerging etiology of chronic kidney disease (CKD). Evidence regarding this causative relationship has been shown by several studies. Recently, Lin conducted the first community-based study investigating the association between CKD prevalence and air pollutant levels utilizing a Fuzzy Logic Interference model. Despite the study's limitations, the results correlate with the previous meta-analysis and observational studies. Higher fine particular matter (PM2.5) levels are associated with the increased global burden of CKD and may also influence the unequal distribution of burden in low-to-middle income countries. Despite growing evidence of the association of air pollution with CKD risk, the underlying pathophysiology has yet to be fully understood. Future studies investigating the pathophysiology and efficiency of the potential therapeutic and preventive measures against air pollution-related kidney injury are required to reduce the CKD burden.
空气污染是慢性肾脏病（CKD）一种新出现的病因。多项研究已证实了这种因果关系的证据。最近，林进行了第一项基于社区的研究，利用模糊逻辑干扰模型调查慢性肾脏病患病率与空气污染物水平之间的关联。尽管该研究存在局限性，但其结果与之前的荟萃分析和观察性研究相关。更高的细颗粒物（PM2.5）水平与慢性肾脏病全球负担增加相关，并且可能也影响低收入和中等收入国家负担的不平等分布。尽管空气污染与慢性肾脏病风险之间关联的证据越来越多，但其潜在的病理生理学仍未被完全理解。需要开展未来研究来调查针对空气污染相关肾损伤的潜在治疗和预防措施的病理生理学及效果，以减轻慢性肾脏病负担。
