School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Monash Health, Melbourne, Victoria, Australia.
Diabetes Care. 2022 Nov 1;45(11):2611-2619. doi: 10.2337/dc22-0951.
The Continuous Glucose Monitoring (CGM) Initiative recently introduced universal subsidized CGM funding for people with type 1 diabetes under 21 years of age in Australia. We thus aimed to evaluate the cost-effectiveness of this CGM Initiative based on national implementation data and project the economic impact of extending the subsidy to all age-groups.
We used a patient-level Markov model to simulate disease progression for young people with type 1 diabetes and compared government-subsidized access to CGM with the previous user-funded system. Three years of real-world clinical input data were sourced from analysis of the Australasian Diabetes Data Network and National Diabetes Services Scheme registries. Costs were considered from the Australian health care system's perspective. An annual discount rate of 5% was applied to future costs and outcomes. Uncertainty was evaluated with probabilistic and deterministic sensitivity analyses.
Government-subsidized CGM funding for young people with type 1 diabetes compared with a completely user-funded model resulted in an incremental cost-effectiveness ratio (ICER) of AUD 39,518 per quality-adjusted life-year (QALY) gained. Most simulations (85%) were below the commonly accepted willingness-to-pay threshold of AUD 50,000 per QALY gained in Australia. Sensitivity analyses indicated that base-case results were robust, though strongly impacted by the cost of CGM devices. Extending the CGM Initiative throughout adulthood resulted in an ICER of AUD 34,890 per QALY gained.
Providing subsidized access to CGM for people with type 1 diabetes was found to be cost-effective compared with a completely user-funded model in Australia.
澳大利亚的连续血糖监测(CGM)倡议最近为 21 岁以下的 1 型糖尿病患者引入了普遍的补贴 CGM 资金。因此,我们旨在根据国家实施数据评估该 CGM 倡议的成本效益,并预测将补贴扩大到所有年龄段的经济影响。
我们使用患者水平的马尔可夫模型来模拟 1 型糖尿病年轻人的疾病进展,并将政府补贴的 CGM 接入与之前的用户资助系统进行比较。三年的真实世界临床输入数据来自对澳大利亚糖尿病数据网络和国家糖尿病服务计划登记处的分析。成本从澳大利亚医疗保健系统的角度考虑。未来的成本和结果应用 5%的年度贴现率进行贴现。使用概率和确定性敏感性分析评估不确定性。
与完全用户资助模式相比,为 1 型糖尿病青少年提供政府补贴的 CGM 资金导致每获得一个质量调整生命年(QALY)的增量成本效益比(ICER)为 39518 澳元。大多数模拟(85%)低于澳大利亚普遍接受的每获得一个 QALY 愿意支付的 50000 澳元的阈值。敏感性分析表明,基本情况结果是稳健的,尽管受到 CGM 设备成本的强烈影响。将 CGM 倡议扩展到成年期,每获得一个 QALY 的 ICER 为 34890 澳元。
与完全用户资助模式相比,为澳大利亚的 1 型糖尿病患者提供补贴的 CGM 接入被认为是具有成本效益的。