Association of and Polymorphisms with Type 2 Diabetes in the Chinese Han Populations.

BACKGROUND

Type 2 diabetes mellitus (T2DM) is caused by diverse environmental and genetic risk factors. Previous studies have reported that cytochrome P450 () is a promising gene for T2DM. Therefore, we aimed to determine the effects of and polymorphisms on T2DM susceptibility among the Chinese Han population.

METHODS

A case-control study was conducted to assess the potential relationship of four polymorphisms (rs8192879, rs12542233, rs2070672 and rs2515641) with T2DM susceptibility in the Chinese population, involving 512 T2DM patients and 515 age- and gender-matched healthy individuals. We used the Agena MassARRAY platform to detect and polymorphisms. The relationship between genetic polymorphisms and T2DM risk was evaluated using odds ratios (ORs) and 95% confidence intervals (CIs) in various genetic models.

RESULTS

After adjusting for age and gender, rs12542233 in the gene was significantly associated with decreased T2DM risk (recessive: OR = 0.67, 95% CI = 0.49-0.91, = 0.012; after FDR correction, = 0.048). The rs12542233 was associated with a reduced risk of T2DM in people over 59 years of age ( = 0.010). In the population with BMI ≤ 24 kg/m, rs12542233 was associated with an increased risk of T2DM ( < 0.05). In the population with BMI > 24 kg/m, rs2515641 can significantly reduce the risk of T2DM ( < 0.05). And rs8192879, rs2070672 and rs2515641 could significantly increase the risk of diabetes retinopathy in T2DM patients ( < 0.05). Furthermore, the TC haplotype was significantly associated with T2DM ( = 0.019).

CONCLUSION

and polymorphisms may contribute to T2DM susceptibility in the Chinese Han population, especially in stratified analysis.