铱/膦-烯烃催化剂实现的环烯烃的不对称α-甲基C(sp³)-H键加成反应。
Asymmetric addition of an -methyl C(sp)-H bond to cyclic alkenes enabled by an iridium/phosphine-olefin catalyst.
作者信息
Sakamoto Kana, Nishimura Takahiro
机构信息
Department of Chemistry, Graduate School of Science, Osaka Metropolitan University, Sumiyoshi, Osaka 558-8585, Japan.
出版信息
Chem Commun (Camb). 2022 Oct 20;58(84):11783-11786. doi: 10.1039/d2cc04642c.
PMID:36172832
Abstract
Iridium-catalyzed asymmetric C-H addition of an -methyl group on 3-trifluoromethyl-2-(-methylamino)pyridine to cyclic alkenes was realized by using a phosphine-olefin ligand. Indene and its 7-substituted derivatives, acenaphthylene, and some bicyclic alkenes underwent the addition to give the corresponding products in good yields with high enantioselectivity.
摘要
通过使用膦-烯烃配体实现了铱催化的3-三氟甲基-2-（-甲基氨基）吡啶上的-甲基对环状烯烃的不对称C-H加成反应。茚及其7-取代衍生物、苊以及一些双环烯烃都能发生该加成反应，以良好的产率和高对映选择性得到相应产物。
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