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大麻二酚治疗自闭症谱系障碍:一项病例研究。

Cannabidiol in Treatment of Autism Spectrum Disorder: A Case Study.

作者信息

Ma Lucy, Platnick Sofia, Platnick Howard

机构信息

Engineering Science, University of Toronto, Toronto, CAN.

Health Sciences, Wilfrid Laurier University, Toronto, CAN.

出版信息

Cureus. 2022 Aug 26;14(8):e28442. doi: 10.7759/cureus.28442. eCollection 2022 Aug.

Abstract

This case study aims to demonstrate the use of cannabidiol (CBD) with low-dose tetrahydrocannabinol (THC) in managing symptoms associated with autism spectrum disorder (ASD) to increase the overall quality of life for these individuals and their families. ASD is a neurodevelopmental disorder affecting cognitive development, behavior, social communication, and motor skills. Despite the increasing awareness of ASD, there is still a lack of safe and effective treatment options. The study includes a nine-year-old male patient who was diagnosed with nonverbal ASD. He exhibited emotional outbursts, inappropriate behaviors, and social deficits including challenges in communicating his needs with others. Since the patient was unable to attain independence at school and at home, his condition was a significant burden to his caregivers. The patient was treated with full-spectrum high CBD and low THC oil formulation, with each milliliter containing 20 mg of CBD and <1 mg of THC. CBD oil starting dose was 0.1ml twice daily, increased every three to four days to 0.5ml twice daily. Overall, the patient experienced a reduction in negative behaviors, including violent outbursts, self-injurious behaviors, and sleep disruptions. There was an improvement in social interactions, concentration, and emotional stability. A combination of high CBD and low-dose THC oil was demonstrated to be an effective treatment option for managing symptoms associated with autism, leading to a better quality of life for both the patient and the caregivers.

摘要

本案例研究旨在证明使用含有低剂量四氢大麻酚(THC)的大麻二酚(CBD)来管理与自闭症谱系障碍(ASD)相关的症状,以提高这些个体及其家庭的整体生活质量。ASD是一种影响认知发展、行为、社交沟通和运动技能的神经发育障碍。尽管对ASD的认识不断提高,但仍然缺乏安全有效的治疗选择。该研究包括一名九岁男性患者,他被诊断为非言语型ASD。他表现出情绪爆发、不当行为和社交缺陷,包括在与他人沟通需求方面存在困难。由于该患者在学校和家中都无法实现独立,他的状况对其照顾者来说是一个沉重负担。该患者接受了全谱高CBD和低THC油制剂治疗,每毫升含有20毫克CBD和<1毫克THC。CBD油起始剂量为每天两次,每次0.1毫升,每三到四天增加至每天两次,每次0.5毫升。总体而言,该患者的负面行为有所减少,包括暴力爆发、自我伤害行为和睡眠障碍。社交互动、注意力和情绪稳定性都有所改善。高CBD和低剂量THC油的组合被证明是管理与自闭症相关症状的有效治疗选择,为患者和照顾者带来了更好的生活质量。

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