单细胞转录组分析 Treg。

Single-Cell Transcriptome Analysis of Treg.

机构信息

Division of Genomics & Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.

Department of Life Sciences, Imperial College London, London, UK.

出版信息

Methods Mol Biol. 2023;2559:259-278. doi: 10.1007/978-1-0716-2647-4_17.

DOI:10.1007/978-1-0716-2647-4_17

PMID:36180638

Abstract

Regulatory T-cells (Treg) are considerably heterogeneous. Thymically derived Treg (tTreg) are those, which differentiate in the thymus, while peripherally derived Treg (pTreg) differentiate from peripheral mature CD4 T-cells. These two populations are often identified using markers such as neuropilin-1 and Helios (for tTreg) and ROR-γt (for pTreg) in intestines (Tanoue et al., Nat Rev Immunol 16:295-309, 2016).

摘要

调节性 T 细胞（Treg）具有显著的异质性。胸腺来源的 Treg（tTreg）是在胸腺中分化的，而外周来源的 Treg（pTreg）则由外周成熟的 CD4 T 细胞分化而来。这两种群体通常使用神经纤毛蛋白-1 和 Helios（用于 tTreg）以及 ROR-γt（用于 pTreg）等标志物在肠道中进行鉴定（Tanoue 等人，Nat Rev Immunol 16:295-309, 2016）。