Two-year motor outcomes associated with the dose of NICU based physical therapy: The Noppi RCT.

BACKGROUND

Interventions involving both the parent and the preterm infant have demonstrated lasting effects on cognitive outcomes, but motor effects are less salient. It remains unclear when to commence early intervention and if dosages have impact on motor outcomes.

AIMS

To examine the effect on motor performance at 24-months corrected age following a parent-administered intervention performed with infants born preterm in the NICU. Intervention dosing and longitudinal motor performance were also analyzed.

STUDY DESIGN

Single-blinded randomized multicenter clinical trial.

SUBJECTS

153 infants born, gestational age ≤ 32 weeks at birth, were randomized into intervention or control group.

OUTCOME MEASURES

Infant Motor Performance Screening Test, Test of Infant Motor Performance, Peabody Developmental Motor Scales-2.

RESULTS

No significant difference was found between the intervention and the control group assessed with the PDMS-2 at 24-months CA. However, a significant positive association was found between dosing and the Gross Motor and Total Motor PDMS-2 scores. Analysis of longitudinal motor performance showed a decreasing motor performance between 6- and 24-months corrected age in both groups.

CONCLUSIONS

There was no difference in motor performance between groups at 24-months corrected age. However, increased intervention dosage was positively associated with improved motor outcome.