College of Animal Science and Technology, Jilin Agricultural University, Changchun, China; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Microb Pathog. 2022 Dec;173(Pt A):105810. doi: 10.1016/j.micpath.2022.105810. Epub 2022 Sep 29.
Porcine reproductive and respiratory syndrome virus (PRRSV) and Porcine circovirus (PCV) are two important pathogens, which caused respiratory disease in pigs. PRRSV and PCV2 had caused great economic losses to the pig industry. Pigs coinfection with PCV2 and PRRSV were common in the clinic, PCV2 antibodies can be detected in most of the pigs. PCV2d and HP-PRRSV(JXA1-like) were two major viruses circulating in the pigs in China. In this study, HP-PRRSV (JXA1-like) and PCV2d were used to coinfect and (or) sequential infect 5-week-old weaned PCV2-antibody positive pigs and the clinical indications, pathological, virus load, and specific antibodies of the challenged post-weaned piglets were evaluated. Thirty 5-week-old post-weaned pigs were divided into six groups infected with PBS, PCV2, PRRSV, PCV2-PRRSV, PRRSV-PCV2, and Co-PRRSV-PCV2 according to the PCV2 specific antibodies. Pigs infected with PRRSV can experience diarrhea, increased body temperature, weight loss, and even death. The pigs in the PRRSV infected group and PRRSV-PCV2 infected group showed severe clinical symptoms, high mortality, and low average daily gain. The main pathological changes were widening of the lung interstitium, lung adhesion, and so on. The PRRSV-PCV2 infected group showed high levels of TNF-α and IL-2. In conclusion, PRRSV and PRRSV-PCV2 sequential infected pigs showed most pathogenic signs, and PCV2-PRRSV sequential infected pigs showed less pathogenicity than pigs of PCV2 and PRRSV coinfection and PRRSV monoinfection from day 10-14, partially suppressing the cytokine storm produced by PRRSV.
猪繁殖与呼吸综合征病毒（PRRSV）和猪圆环病毒（PCV）是两种重要的病原体，它们可导致猪的呼吸道疾病。PRRSV 和 PCV2 给养猪业造成了巨大的经济损失。猪同时感染 PCV2 和 PRRSV 在临床上很常见，大多数猪都能检测到 PCV2 抗体。PCV2d 和 HP-PRRSV（JXA1 样）是中国猪群中两种主要流行的病毒。在本研究中，使用 HP-PRRSV（JXA1 样）和 PCV2d 对已感染 PCV2 抗体阳性的 5 周龄断奶仔猪进行共感染和（或）顺序感染，并评估了感染后仔猪的临床症状、病理变化、病毒载量和特异性抗体。根据 PCV2 特异性抗体，将 30 头 5 周龄断奶仔猪分为 6 组，分别感染 PBS、PCV2、PRRSV、PCV2-PRRSV、PRRSV-PCV2 和 Co-PRRSV-PCV2。感染 PRRSV 的猪会出现腹泻、体温升高、体重减轻甚至死亡。PRRSV 感染组和 PRRSV-PCV2 感染组的猪表现出严重的临床症状、高死亡率和低平均日增重。主要的病理变化为肺间质增宽、肺粘连等。PRRSV-PCV2 感染组的 TNF-α 和 IL-2 水平较高。综上所述，PRRSV 和 PRRSV-PCV2 顺序感染的仔猪表现出大多数的致病性症状，而 PCV2-PRRSV 顺序感染的仔猪在第 10-14 天的致病性比 PCV2 和 PRRSV 共感染和 PRRSV 单独感染的仔猪低，部分抑制了 PRRSV 产生的细胞因子风暴。
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