通过7天的全身溶栓成功治疗急性症状性广泛门静脉系统血栓形成。
Successful treatment of acute symptomatic extensive portal venous system thrombosis by 7-day systemic thrombolysis.
作者信息
Gao Fang-Bo, Wang Le, Zhang Wen-Xiu, Shao Xiao-Dong, Guo Xiao-Zhong, Qi Xing-Shun
机构信息
Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang 110840, Liaoning Province, China.
Postgraduate College, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China.
出版信息
World J Gastrointest Surg. 2022 Sep 27;14(9):1082-1085. doi: 10.4240/wjgs.v14.i9.1082.
Acute portal venous system thrombosis (PVST) can cause acute mesenteric ischemia and even intestinal infarction, which are potentially fatal, and requires recanalization in a timely fashion. Herein, we report a 56-year-old man with acute non-cirrhotic symptomatic extensive PVST who achieved portal vein recanalization after systemic thrombolysis combined with anticoagulation. Initially, anticoagulation with enoxaparin sodium for 4 d was ineffective, and then systemic thrombolysis for 7 d was added. After that, his abdominal pain completely disappeared, and portal vein system vessels became gradually patent. Long-term anticoagulation therapy was maintained. In conclusion, 7-d systemic thrombolysis may be an effective and safe choice of treatment for acute symptomatic extensive PVST which does not respond to anticoagulation therapy.
急性门静脉系统血栓形成（PVST）可导致急性肠系膜缺血甚至肠梗死，这些情况具有潜在致命性，需要及时进行再通治疗。在此，我们报告一名56岁男性，患有急性非肝硬化症状性广泛PVST，在全身溶栓联合抗凝治疗后实现了门静脉再通。最初，使用依诺肝素钠抗凝4天无效，随后添加了7天的全身溶栓治疗。此后，他的腹痛完全消失，门静脉系统血管逐渐通畅。维持了长期抗凝治疗。总之，对于对抗凝治疗无反应的急性症状性广泛PVST，7天的全身溶栓可能是一种有效且安全的治疗选择。
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