Adar Adem, Onalan Orhan, Cakan Fahri, Keles Hakan, Akbay Ertan, Akıncı Sinan, Coner Ali, Haberal Cevahir, Muderrisoglu Haldun
Department of Cardiology, Baskent University Faculty of Medicine, Alanya, Turkey.
Department of Cardiology, Karabuk University Faculty of Medicine, Karabuk, Turkey.
Acta Cardiol. 2022 Dec;77(10):943-949. doi: 10.1080/00015385.2022.2121537. Epub 2022 Oct 3.
Para-aortic adipose tissue (PAT) is the local adipose tissue that externally surrounds the aorta. It contributes significantly to aortic atherosclerosis and enlargement. Studies conducted with computed tomography and magnetic resonance have shown that individuals with aortic aneurysm had more PAT than healthy individuals. In this study, we measured PAT using transthoracic echocardiography (TTE). The aim of this study is to investigate the possible relationship of TTE measured PAT with ascending aortic width.
PAT was defined as the hypoechoic space in front of ascending aortic 2 cm above the sinotubular junction at the end of the systole. Patients were divided into 2 groups according to the presence of dilatation in the ascending aorta using Roman's classification (aortic size index, ASI). ASI of less than 21 was considered no aortic dilation and an ASI of 21 mm/m2 or greater was considered to have aortic dilation.
A total of 321 unselected patients were divided into the ascending aortic dilatation (AAD) group ( = 96) and the normal ascending aorta diameter group ( = 225 patients). PAT was significantly higher in the AAD group compared with the non-ADD group (0.9 (0.48) vs. 0.7 (0.91) mm, < 0.0001). Univariate and multivariate logistic regression analysis revealed that PAT (OR: 3.005, 95%CI (1.445-6.251)) were significantly associated with AAD.
This is the first study which evaluated PAT measured by TTE. We found a significant association between PAT measured by TTE and ascending aorta width.
主动脉旁脂肪组织（PAT）是在主动脉外部环绕的局部脂肪组织。它对主动脉粥样硬化和扩张有显著影响。计算机断层扫描和磁共振成像研究表明，主动脉瘤患者的PAT比健康人更多。在本研究中，我们使用经胸超声心动图（TTE）测量PAT。本研究的目的是探讨TTE测量的PAT与升主动脉宽度之间可能存在的关系。
PAT定义为收缩期末在窦管交界处上方2cm处升主动脉前方的低回声区。根据升主动脉是否扩张，采用罗马分类法（主动脉大小指数，ASI）将患者分为两组。ASI小于21被认为无主动脉扩张，ASI为21mm/m2或更大被认为有主动脉扩张。
共321例未经选择的患者被分为升主动脉扩张（AAD）组（n = 96）和升主动脉直径正常组（n = 225例患者）。AAD组的PAT显著高于非AAD组（0.9（0.48）对0.7（0.91）mm，P < 0.0001）。单因素和多因素逻辑回归分析显示，PAT（OR：3.005，95%CI（1.445 - 6.251））与AAD显著相关。
这是第一项评估通过TTE测量的PAT的研究。我们发现通过TTE测量的PAT与升主动脉宽度之间存在显著关联。
