Brown D L, Bulley C K, Quiel E L
Anesth Analg. 1987 Sep;66(9):869-73.
Neurolytic celiac plexus block (NCPB) is an effective method for relief of the pain of pancreatic cancer, but many physicians are reluctant to use the technique because of the perception that the incidence of complications is high. We analyzed the incidence of complications and the quality of pain relief obtained during the use of NCPB in 136 patients with pancreatic cancer. Eighty-five percent of the patients had good pain relief that, in 75% of cases, lasted through the patients' remaining life. No permanent neurologic complications resulted, although two patients had a pneumothorax. Radiographically guided needle placement did not affect quality of pain relief or the incidence of complications. This neurolytic pain block is effective, has a low incidence of neurologic complications, and deserves more widespread use in patients with pancreatic cancer.
腹腔神经丛毁损术（NCPB）是缓解胰腺癌疼痛的一种有效方法，但许多医生因认为并发症发生率高而不愿使用该技术。我们分析了136例胰腺癌患者在接受NCPB治疗期间的并发症发生率及疼痛缓解质量。85%的患者疼痛得到良好缓解，其中75%的病例疼痛缓解持续至患者生命结束。虽然有两名患者发生气胸，但未出现永久性神经并发症。影像学引导下的穿刺针放置并不影响疼痛缓解质量或并发症发生率。这种神经毁损性疼痛阻滞有效，神经并发症发生率低，值得在胰腺癌患者中更广泛地应用。
