Poehlmann John R, Avery Gabrielle, Antony Kathleen M, Broman Aimee Teo, Godecker Amy, Green Tiffany L
Department of Obstetrics & Gynecology, University of Wisconsin-Madison, Madison, WI, USA.
Department of Obstetrics & Gynecology, Division of Maternal Fetal Medicine, University of Wisconsin-Madison, Madison, WI, USA.
J Matern Fetal Neonatal Med. 2022 Dec;35(26):10305-10313. doi: 10.1080/14767058.2022.2124368. Epub 2022 Oct 4.
To evaluate racial/ethnic differences in post-operative pain experience and opioid medication use (morphine milligram equivalent) in the first 24 h following cesarean birth.
This study was a single-center retrospective cohort of birthing persons who underwent cesarean deliveries between 1/1/16 and 12/31/17. A total of 2,228 cesarean deliveries were analyzed. The primary outcome was average pain, which was the mean of all documented self-reported pain scores (0-10 scale) during the first 24 h post-delivery. The secondary outcome included oral morphine equivalents used in the first 24 h post-delivery. Linear regression was performed to examine whether the race/ethnicity of the birthing parent was associated with mean pain scores and oral morphine equivalents, controlling for confounding variables.
In multivariate analyses non-Hispanic Black birthing persons reported higher mean pain scores (Coefficient: 0.61, 95% confidence interval [0.39-0.82], < .001]) than non-Hispanic White birthing persons, but received similar quantities of morphine milligram equivalent (Coefficient: -0.98 mg, 95% confidence interval [-5.93-3.97], = .698]). Non-Hispanic Asian birthing persons reported similar reported mean pain scores to those of non-Hispanic White birthing persons (Coefficient: 0.02 mg, 95% confidence interval [-0.17-0.22], = .834]), but received less morphine milligram equivalent (Coefficient: -5.47 mg, 95% confidence interval [-10.05 to -0.90], = .019). When controlling for reported mean pain scores, both non-Hispanic Black (Coefficient: -6.36 mg, 95% confidence interval [-10.97 to -1.75], = .007) and non-Hispanic Asian birthing persons (Coefficient: -5.66 mg, 95% confidence interval [-9.89 to -1.43], = .009) received significantly less morphine milligram equivalents.
Despite reporting higher mean pain scores, non-Hispanic Black birthing persons did not receive higher quantities of morphine milligram equivalent. Non-Hispanic Asian birthing persons received lower quantities of morphine milligram equivalent despite reporting similar pain scores to non-Hispanic White birthing persons. These differences suggest disparities in post-operative pain management for birthing persons of color in our study population.
评估剖宫产术后24小时内不同种族/族裔产妇的疼痛体验及阿片类药物使用情况(吗啡毫克当量)。
本研究为单中心回顾性队列研究,纳入了2016年1月1日至2017年12月31日期间行剖宫产的产妇。共分析了2228例剖宫产病例。主要结局为平均疼痛程度,即产后24小时内所有记录的自我报告疼痛评分(0 - 10分)的平均值。次要结局包括产后24小时内使用的口服吗啡当量。进行线性回归分析,以检验产妇的种族/族裔与平均疼痛评分及口服吗啡当量之间是否存在关联,并对混杂变量进行控制。
在多变量分析中,非西班牙裔黑人产妇报告的平均疼痛评分高于非西班牙裔白人产妇(系数:0.61,95%置信区间[0.39 - 0.82],P <.001),但接受的吗啡毫克当量相似(系数: - 0.98mg,95%置信区间[-5.93 - 3.97],P =.698)。非西班牙裔亚洲产妇报告的平均疼痛评分与非西班牙裔白人产妇相似(系数:0.02mg,95%置信区间[-0.17 - 0.22],P =.834),但接受的吗啡毫克当量较少(系数: - 5.47mg,95%置信区间[-10.05至 - 0.90],P =.019)。在控制报告的平均疼痛评分后,非西班牙裔黑人产妇(系数: - 6.36mg,95%置信区间[-10.97至 - 1.75],P =.007)和非西班牙裔亚洲产妇(系数: - 5.66mg,95%置信区间[-9.89至 - 1.43],P =.009)接受的吗啡毫克当量均显著较少。
尽管非西班牙裔黑人产妇报告的平均疼痛评分较高,但接受的吗啡毫克当量并未更高。非西班牙裔亚洲产妇接受的吗啡毫克当量较低,尽管其报告的疼痛评分与非西班牙裔白人产妇相似。这些差异表明我们研究人群中有色人种产妇在术后疼痛管理方面存在差异。