ANN ARBOR, MICHIGAN.
Trans Am Clin Climatol Assoc. 2022;132:22-33.
Neutrophils (PMNs) play a critical role in innate immunity, yet many pathologic conditions are associated with dysregulated infiltration of PMNs into tissues. In the gut, robust PMN accumulation and migration across the intestinal epithelium closely correlates with clinical symptoms in conditions such as ulcerative colitis. While much is known about how PMNs migrate out of blood vessels, far less is understood about how PMNs traverse epithelial barriers. Until fairly recently, models of PMN transepithelial migration (TEpM) across cultured intestinal epithelial cell lines provided many of the insights into the molecular basis of TEpM. However, innovative animal models have provided new avenues for investigating mechanisms regulating PMN TEpM. This report will highlight molecular insights gained from studies on PMN TEpM and provide a rationale for developing tissue targeted strategies directed at reducing pathologic consequences of dysregulated PMN trafficking in the gut.
中性粒细胞（PMN）在先天免疫中发挥着关键作用，但许多病理状况都与PMN异常浸润组织有关。在肠道中，大量PMN的积累和穿过肠上皮的迁移与溃疡性结肠炎等疾病的临床症状密切相关。虽然人们已经了解了PMN如何从血管中迁移出来，但对于PMN如何穿过上皮屏障知之甚少。直到最近，PMN穿过培养的肠上皮细胞系的跨上皮迁移（TEpM）模型为TEpM 的分子基础提供了许多见解。然而，创新的动物模型为研究调节PMN TEpM 的机制提供了新途径。本报告将重点介绍PMN TEpM 研究中获得的分子见解，并为开发针对肠道中PMN 异常迁移的病理后果的靶向组织策略提供依据。
