Almazov National Medical Research Centre, 197341 Akkuratova str. 2b, Saint Petersburg, Russian Federation.
Almazov National Medical Research Centre, 197341 Akkuratova str. 2b, Saint Petersburg, Russian Federation; Research Institute of Obstetrics and Gynecology Named After D.O. Ott (branch of Russian Academy of Medical Sciences), 199034 Mendeleevskaya line 3, Saint Petersburg, Russian Federation.
Placenta. 2022 Nov;129:36-42. doi: 10.1016/j.placenta.2022.09.003. Epub 2022 Sep 27.
Enzymes, including matrix metalloproteinases (MMPs), play a significant role in trophoblast invasion - the cornerstone of preeclampsia pathogenesis.
This study aimed to explore the dynamics of the MMP-12 concentration in blood serum during the gestational period at determined weeks in preeclampsia and physiological pregnancy to compare the results with the expression of MMP-12 in placental tissue and reveal the MMP-12 predicting role in preeclampsia.
Circulating serum MMP-12 was significantly decreased. The level of 0.5 ng/ml had high sensitivity and low false positivity at 11-13 weeks of pregnancy in women destined to develop pre-eclampsia in the case-control study. The dynamics curve of serum MMP-12 varied between study groups: a sharp decrease in MMP-12 concentration was found from the first trimester to the second trimester, followed by a slight increase in the third trimester of pregnancy in controls compared to the increase in concentration from the first trimester to the second trimester in pre-eclampsia. The absence of a significant difference in the concentration of MMP-12 in the II and III trimesters as well as no difference in the expression of MMP-12 protein in placental tissue in the third trimester indicates a decrease in its role after the end of placentation.
To our knowledge, this is the first study to show the dynamics of serum MMP-12 concentration during the gestational period and indicates a significant role for MMP-12 in the initial stages of placentation. The data obtained may pave the way to new early prediction strategies for preeclampsia.
酶，包括基质金属蛋白酶（MMPs），在滋养细胞侵袭中起着重要作用 - 子痫前期发病机制的基石。
本研究旨在探讨 MMP-12 浓度在子痫前期和生理妊娠的妊娠期间特定周的血清中的动力学，以比较结果与 MMP-12 在胎盘组织中的表达，并揭示 MMP-12 在子痫前期中的预测作用。
循环血清 MMP-12 显著降低。在病例对照研究中，在 11-13 周的妊娠中，患有子痫前期的女性的血清 MMP-12 水平为 0.5ng/ml 时具有高灵敏度和低假阳性率。血清 MMP-12 的动力学曲线在研究组之间有所不同：与子痫前期的浓度从第一季度到第二季度增加相比，对照组中 MMP-12 浓度从第一季度到第二季度急剧下降，然后在妊娠的第三个三个月中略有增加。在第二和第三个三个月中 MMP-12 的浓度没有显著差异，以及在第三个三个月的胎盘组织中 MMP-12 蛋白的表达没有差异，表明在胎盘形成结束后其作用降低。
据我们所知，这是第一项显示妊娠期间血清 MMP-12 浓度动态的研究，并表明 MMP-12 在胎盘形成的初始阶段起着重要作用。获得的数据可能为子痫前期的新的早期预测策略铺平道路。
