Department Zhang Dayu School of Chemistry, Dalian University of Technology, 116024, Dalian, Liaoning, P. R. China.
Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-Ku, 060-0812, Sapporo, Japan.
Chemistry. 2023 Jan 2;29(1):e202202385. doi: 10.1002/chem.202202385. Epub 2022 Nov 16.
Herein, we report visible light-promoted single nickel catalysis for diverse carbon-heteroatom couplings under mild conditions. This mild, general, and robust method to couple diverse nitrogen, oxygen, and sulfur nucleophiles with aryl(heteroaryl)/alkenyl iodides/bromides exhibits a wide functional group tolerance and is applicable to late-stage modification of pharmaceuticals and natural products. On the base of preliminary mechanistic studies, a Ni /Ni cycle via the generation of active Ni complexes that appear from homolysis of Ni -I rather than Ni -aryl bond was tentatively proposed.
在这里，我们报告了在温和条件下可见光促进的单镍催化的多种碳-杂原子偶联。这种温和、通用且强大的方法可以将各种氮、氧和硫亲核试剂与芳基（杂芳基）/烯基碘化物/溴化物偶联，具有广泛的官能团容忍性，适用于药物和天然产物的后期修饰。基于初步的机理研究，我们提出了一个通过 Ni -I 的均裂而不是 Ni-芳基键生成活性 Ni 配合物的 Ni /Ni 循环的假设。
