Krankowska Dagny C, Załęski Andrzej, Wiercińska-Drapało Alicja
Department of Infectious and Tropical Diseases and Hepatology, 37803Medical University of Warsaw, Poland.
Hospital for Infectious Diseases, Warsaw, Poland.
Int J STD AIDS. 2022 Nov;33(13):1106-1110. doi: 10.1177/09564624221127744. Epub 2022 Oct 11.
With the increasing lifespan of people living with HIV (PLWH), frailty and prefrailty are becoming topics which require more attention. The reciprocal interactions between chronic inflammation, comorbidities and frailty demonstrate the complex pathophysiology of frailty and its consequences. Female sex, HIV infection without antiretroviral treatment, reduced CD4 cell count, depression and cardiovascular disease are some of the risk factors for frailty among PLWH. Frailty predisposes to falls and can therefore lead to more frequent fractures, hospitalization and death, especially in women with osteoporosis. Continuous antiretroviral treatment, prevention of comorbidities such as depression and diagnosis of prefrailty are crucial interventions to slow the development of frailty. This review summarizes the literature on frailty in people living with HIV and discusses frailty management strategies in order to improve the health outcomes in women living with HIV.
随着人类免疫缺陷病毒（HIV）感染者寿命的延长，虚弱和脆弱前期正成为需要更多关注的话题。慢性炎症、合并症与虚弱之间的相互作用表明了虚弱及其后果的复杂病理生理学。女性、未接受抗逆转录病毒治疗的HIV感染、CD4细胞计数降低、抑郁症和心血管疾病是HIV感染者中虚弱的一些危险因素。虚弱易导致跌倒，因此可能导致更频繁的骨折、住院和死亡，尤其是在患有骨质疏松症的女性中。持续的抗逆转录病毒治疗、预防抑郁症等合并症以及对脆弱前期的诊断是减缓虚弱发展的关键干预措施。本综述总结了关于HIV感染者虚弱的文献，并讨论了虚弱管理策略，以改善HIV感染女性的健康结局。
