COL11A1 作为口腔鳞状细胞癌的潜在预后靶点。
COL11A1 as a potential prognostic target for oral squamous cell carcinoma.
机构信息
Department of Stomatology, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China.
Department of Stomatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China.
出版信息
Medicine (Baltimore). 2022 Oct 7;101(40):e30989. doi: 10.1097/MD.0000000000030989.
Oral squamous cell carcinoma (OSCC) is a malignant tumor occurring in the oral cavity. However, the molecular mechanism of OSCC is not clear. Bioinformatics was used to screen and identify role of collagen type X1 alpha 1 (COL11A1) on OSCC. 200 patients with OSCC were recruited. Clinical and follow-up data were recorded and COL11A1 expression levels were tested. Pearson chi-square test and Spearman correlation coefficient were used to analyze relationship between prognosis and related parameters in patients with OSCC. Univariate and multivariate Logistic regression, univariate and multivariate Cox proportional risk regression were used for further analysis, survival curve was drawn. Through bioinformatics analysis, OSCC patients with higher expression of COL11A1 have poor overall survival compare with OSCC patients with lower expression of COL11A1 (hazard ratios [HR] = 1.32, P = .047). Pearson chi-square test showed that age (P = .011), tumor grade (P = .023), COL11A1 (P < .001) was significantly correlated with prognosis of OSCC. Univariate Logistic regression analysis showed age (odds ratio [OR] = 2.102, 95% confidence intervals [95%CI]: 1.180-3.746, P = .012), tumor grade (OR = 1.919, 95%CI: 1.093-3.372, P = .023) and COL11A1 (OR = 12.775, 95%CI: 6.509-25.071, P < .001). Multivariate Logistic regression analysis showed that COL11A1 (OR = 12.066, 95%CI: 6.042-24.096, P < .001) was significantly associated with prognosis of patients with OSCC. Univariate Cox regression analysis showed that age (HR = 1.592, 95%CI: 1.150-2.205, P = .005), tumor grade (HR = 1.460, 95%CI: 1.067-1.999, P = .018) and COL11A1 (HR = 1.848, 95%CI: 1.340-2.548, P < .001) were significantly correlated with survival time of OSCC patients. Multivariate Cox regression analysis showed that tumor grade (HR = 1.466, 95%CI: 1.064-2.020, P = .019) and COL11A1 (HR = 1.645, 95%CI: 1.164-2.325, P = .005) were significantly correlated with survival time of OSCC patients. COL11A1 is significantly correlated with occurrence of OSCC. When COL11A1 is highly expressed, prognosis of patients with OSCC is worse and the survival time is shorter.
口腔鳞状细胞癌（OSCC）是一种发生在口腔的恶性肿瘤。然而，OSCC 的分子机制尚不清楚。本研究采用生物信息学方法筛选和鉴定 COL11A1 在 OSCC 中的作用。招募了 200 名 OSCC 患者。记录临床和随访数据，并检测 COL11A1 表达水平。采用 Pearson 卡方检验和 Spearman 相关系数分析 OSCC 患者预后与相关参数的关系。采用单因素和多因素 Logistic 回归、单因素和多因素 Cox 比例风险回归进行进一步分析，并绘制生存曲线。通过生物信息学分析，COL11A1 高表达的 OSCC 患者的总生存期较 COL11A1 低表达的 OSCC 患者差（风险比[HR] = 1.32，P = 0.047）。Pearson 卡方检验显示，年龄（P = 0.011）、肿瘤分级（P = 0.023）、COL11A1（P < 0.001）与 OSCC 患者的预后显著相关。单因素 Logistic 回归分析显示，年龄（比值比[OR] = 2.102，95%置信区间[95%CI]：1.180-3.746，P = 0.012）、肿瘤分级（OR = 1.919，95%CI：1.093-3.372，P = 0.023）和 COL11A1（OR = 12.775，95%CI：6.509-25.071，P < 0.001）与 OSCC 患者的预后显著相关。多因素 Logistic 回归分析显示，COL11A1（OR = 12.066，95%CI：6.042-24.096，P < 0.001）与 OSCC 患者的预后显著相关。单因素 Cox 回归分析显示，年龄（HR = 1.592，95%CI：1.150-2.205，P = 0.005）、肿瘤分级（HR = 1.460，95%CI：1.067-1.999，P = 0.018）和 COL11A1（HR = 1.848，95%CI：1.340-2.548，P < 0.001）与 OSCC 患者的生存时间显著相关。多因素 Cox 回归分析显示，肿瘤分级（HR = 1.466，95%CI：1.064-2.020，P = 0.019）和 COL11A1（HR = 1.645，95%CI：1.164-2.325，P = 0.005）与 OSCC 患者的生存时间显著相关。COL11A1 与 OSCC 的发生显著相关。当 COL11A1 高表达时，OSCC 患者的预后较差，生存时间较短。
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