使用体外系统的致畸学研究。III. 培养中的胚胎器官。

Teratological research using in vitro systems. III. Embryonic organs in culture.

作者信息

Whitby K E

出版信息

Environ Health Perspect. 1987 Jun;72:221-3. doi: 10.1289/ehp.8772221.

DOI:10.1289/ehp.8772221

PMID:3622436

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1474650/

Abstract

A search of literature published through the spring of 1986 yielded approximately 95 citations for the following embryonic organs in culture: kidney, pancreas, skin, palate, craniofacial tissue, tooth, lens, bones, digits, and liver. However, only the in vitro organ culture of the palate and tooth are reviewed in this paper. The other organ culture systems were not reported as teratogenic screens. Although some organs may have the potential for such use, many are currently used for evaluation of the pathogenesis associated with congenital abnormalities, cancer, or transplacental carcinogenesis, or in studies of the structure and function of differentiating organs, and will not be included in this review.

摘要

检索截至1986年春季发表的文献，得到了约95篇关于以下培养中的胚胎器官的文献引用：肾脏、胰腺、皮肤、腭、颅面组织、牙齿、晶状体、骨骼、指（趾）和肝脏。然而，本文仅综述了腭和牙齿的体外器官培养。其他器官培养系统未被报道用作致畸筛选。尽管一些器官可能有这种用途的潜力，但许多器官目前用于评估与先天性异常、癌症或经胎盘致癌作用相关的发病机制，或用于研究分化器官的结构和功能，因此本综述将不包括这些内容。