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血清乙型肝炎核心相关抗原与乙型肝炎病毒 DNA 阴性状态乙型肝炎肝硬化患者乙型肝炎表面抗原的相关性：一项回顾性研究。

Correlations between serum hepatitis B core-related antigen and hepatitis B surface antigen in patients with hepatitis B cirrhosis and a hepatitis B virus-DNA-negative status: a retrospective study.

机构信息

Department of Hepatology and Gastroenterology, The Third Central Clinical College of Tianjin Medical University, Tianjin, China; Tianjin Institute of Hepatobiliary Disease, Tianjin, China.

Center of Infectious Diseases, Tanggu Infectious Disease Hospital of Tianjin, Tianjin, China.

出版信息

J Int Med Res. 2022 Oct;50(10):3000605221130714. doi: 10.1177/03000605221130714.

DOI:10.1177/03000605221130714

PMID:36224762

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9561681/

Abstract

OBJECTIVE

This study aimed to examine the correlations between serum hepatitis B core-related antigen (HBcrAg) and hepatitis B surface antigen (HBsAg) titers in patients with hepatitis B cirrhosis and a hepatitis B virus (HBV)-DNA-negative status.

METHODS

We retrospectively analyzed the data and blood samples of patients who were diagnosed with HBV liver cirrhosis and an HBV-DNA negative status. These patients were hospitalized between October 2018 and October 2019 at one hospital.

RESULTS

A total of 180 patients were included. The median (interquartile range) HBsAg and HBcrAg concentrations were 2.77 log IU/mL (1.60-3.15) and 3.96 log U/mL (2.70-4.97), respectively. A non-linear significant relationship was found between HBsAg and HBcrAg concentrations. The inflection point was 0.58. The effect size and confidence interval on the left and right sides of the inflection point were 0.10 (-0.23-0.42) and 0.62 (0.46-0.78), respectively. When HBsAg concentrations were ≥0.58 log IU/mL, HBsAg concentrations were positively correlated with HBcrAg concentrations. When HBsAg concentrations increased by 1 log IU/mL, HBcrAg concentrations increased by 0.62 log U/mL (95% confidence interval: 0.46, 0.78).

CONCLUSIONS

There might be a non-linear relationship between HBcrAg and HBsAg concentrations in patients with hepatitis B cirrhosis and an HBV-DNA-negative status.

摘要

目的

本研究旨在探讨乙型肝炎肝硬化且乙型肝炎病毒（HBV）-DNA 阴性患者血清乙型肝炎核心相关抗原（HBcrAg）与乙型肝炎表面抗原（HBsAg）滴度之间的相关性。

方法

我们回顾性分析了 2018 年 10 月至 2019 年 10 月期间在一家医院住院的乙型肝炎肝硬化且 HBV-DNA 阴性患者的数据和血液样本。

结果

共纳入 180 例患者。HBsAg 和 HBcrAg 浓度的中位数（四分位距）分别为 2.77logIU/mL（1.60-3.15）和 3.96logU/mL（2.70-4.97）。HBsAg 和 HBcrAg 浓度之间存在非线性显著关系。拐点为 0.58。拐点左侧和右侧的效应大小和置信区间分别为 0.10（-0.23-0.42）和 0.62（0.46-0.78）。当 HBsAg 浓度≥0.58logIU/mL 时，HBsAg 浓度与 HBcrAg 浓度呈正相关。当 HBsAg 浓度增加 1logIU/mL 时，HBcrAg 浓度增加 0.62logU/mL（95%置信区间：0.46，0.78）。