Johansson B E, Moran T M, Bona C A, Popple S W, Kilbourne E D
J Immunol. 1987 Sep 15;139(6):2010-4.
In man, vaccination with neuraminidase (NA) in H7N2 virus hybrids elicits greater anti-NA response than does N2 NA in H3N2 conventional vaccine, presumably because humans are H3 hemagglutinin (HA) primed and anti-H3 anamnestic response depresses concomitant N2 responses by antigenic competition. In a laboratory model, BALB/c mice were primed by different schedules of infection with H3N1, H3N2, and H3N7 viruses and given H3N2 and H7N2 vaccines equivalent in NA immunogenicity. In schedules using sequential infections, but not after a single infection with any virus, anti-N2 booster response was fourfold greater with H7N2 vaccine and was reciprocal to the magnitude of anti-H3 response. Thus, HA-influenced suppression of immunologic response to viral NA requires adequate HA priming but is not unique to man and can be studied in the murine model. An incidental finding of this study was the sharing of cross-reactive determinants by N1, N2, and N7 NA.
在人类中，用H7N2病毒杂交株中的神经氨酸酶（NA）进行疫苗接种所引发的抗NA反应，比H3N2传统疫苗中的N2 NA引发的反应更强，这可能是因为人类预先接触过H3血凝素（HA），而抗H3的回忆反应通过抗原竞争抑制了同时发生的N2反应。在一个实验室模型中，用不同的感染方案使BALB/c小鼠预先接触H3N1、H3N2和H3N7病毒，并给予NA免疫原性相当的H3N2和H7N2疫苗。在采用连续感染的方案中，但在任何一种病毒单次感染后则不然，H7N2疫苗的抗N2加强反应大四倍，且与抗H3反应的强度呈反比。因此，HA对病毒NA免疫反应的影响需要足够的HA预先接触，但并非人类所特有，可在小鼠模型中进行研究。本研究的一个意外发现是N1、N2和N7 NA存在交叉反应决定簇。
