狼疮性肾炎中的巨噬细胞：探索一条潜在的新治疗途径。
Macrophages in Lupus Nephritis: Exploring a potential new therapeutic avenue.
作者信息
Kwant Lianne E, Vegting Yosta, Tsang-A-Sjoe Michel W P, Kwakernaak Arjan J, Vogt Liffert, Voskuyl Alexandre E, van Vollenhoven Ronald F, de Winther Menno P J, Bemelman Frederike J, Anders Hans-Joachim, Hilhorst Marc L
机构信息
Department of Internal Medicine, Division of Nephrology, Amsterdam UMC, Amsterdam, the Netherlands.
Department of Rheumatology and Clinical Immunology, Amsterdam UMC, Amsterdam, the Netherlands.
出版信息
Autoimmun Rev. 2022 Dec;21(12):103211. doi: 10.1016/j.autrev.2022.103211. Epub 2022 Oct 14.
Lupus nephritis (LN) is a serious complication of systemic lupus erythematosus (SLE) that occurs in about half of patients. LN is characterized by glomerular deposition of immune complexes, leading to subendothelial, mesangial and subepithelial electron dense deposits, triggering immune cell infiltration and glomerular as well as tubulointerstitial injury. Monocytes and macrophages are abundantly present in inflammatory lesions, both in glomeruli and the tubulointerstitium. Here we discuss how monocytes and macrophages are involved in this process and how monocytes and macrophages may represent specific therapeutic targets to control LN.
狼疮性肾炎（LN）是系统性红斑狼疮（SLE）的一种严重并发症，约半数SLE患者会出现该病症。LN的特征是免疫复合物在肾小球沉积，导致内皮下、系膜和上皮下电子致密沉积物形成，引发免疫细胞浸润以及肾小球和肾小管间质损伤。单核细胞和巨噬细胞大量存在于炎症病变中，包括肾小球和肾小管间质。在此，我们将讨论单核细胞和巨噬细胞如何参与这一过程，以及它们如何可能成为控制LN的特定治疗靶点。
Zotero 插件