与乳腺癌中 miRNA 和 Wnt 信号调控相关的机制特征及治疗意义。
Mechanistic Features and Therapeutic Implications Related to the MiRNAs and Wnt Signaling Regulatory in Breast Cancer.
机构信息
Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, 1991953381, Tehran, Iran.
Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences (BUMS), Birjand, Iran.
出版信息
Curr Mol Pharmacol. 2023;16(5):530-541. doi: 10.2174/1874467216666221017122105.
Breast cancer (BC) is accountable for a large number of female-related malignancies that lead to lethality worldwide. Various factors are considered in the occurrence of BC, including the deregulation of cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT). Genetic factors such as microRNAs (miRs) are crucially responsible for BC progression and aggressiveness. Hence, the association of miRs and EMT regulators (e.g., Wnt signaling pathway) is of importance. In the present review, we accurately discussed this interplay (interaction between Wnt and miRs) concerning cell - invasion, -migration, -differentiation, -chemoresistance, survival, and-proliferation, and BC prognosis. The putative therapeutic agents, multidrug resistance (MDR) evade, and possible molecular targets are described as well.
乳腺癌（BC）是导致全球女性相关恶性肿瘤死亡率较高的主要原因。BC 的发生涉及多种因素，包括癌症干细胞（CSCs）和上皮-间充质转化（EMT）的失调。遗传因素如 microRNAs（miRs）对 BC 的进展和侵袭性起着至关重要的作用。因此，miRs 和 EMT 调节剂（例如 Wnt 信号通路）的关联具有重要意义。在本综述中，我们详细讨论了这种相互作用（Wnt 与 miRs 之间的相互作用），涉及细胞侵袭、迁移、分化、化疗耐药、存活和增殖，以及 BC 的预后。还描述了潜在的治疗药物、多药耐药（MDR）规避和可能的分子靶点。
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